Basic information Safety Supplier Related

m-PEG11-acid

Basic information Safety Supplier Related

m-PEG11-acid Basic information

Product Name:
m-PEG11-acid
Synonyms:
  • m-PEG11-acid
  • mPEG10-CH2CH2COOH/2,5,8,11,14,17,20,23,26,29,32-undecaoxapentatriacontan-35-oic acid
  • 3-[2-[2-[2-[2-[2-[2-[2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoic acid
CAS:
2280998-74-3
MF:
C24H48O13
MW:
544.64
Mol File:
2280998-74-3.mol
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m-PEG11-acid Chemical Properties

Boiling point:
599.1±50.0 °C(Predicted)
Density 
1.113±0.06 g/cm3(Predicted)
solubility 
DMSO : 100 mg/mL (183.61 mM; Need ultrasonic)
form 
Liquid
pka
4.28±0.10(Predicted)
color 
Colorless to light yellow
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m-PEG11-acid Usage And Synthesis

Description

m-PEG11-acid is a PEG linker containing a terminal carboxylic acid. The terminal carboxylic acid can be reacted with primary amine groups in the presence of activators (e.g. EDC, or DCC) to form a stable amide bond. The hydrophilic PEG spacer increases solubility in aqueous media.

Biological Activity

M-PEG11-acid is a non-cleavable ADC linker containing 11-unit PEG, which can be used to synthesize antibody drug conjugates (ADC). m-PEG11-acid is also a PROTAC linker, belonging to the PEG class, which can be used to synthesize PROTAC molecules.

in vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

target

PEGs

Non-cleavable

m-PEG11-acidSupplier

Jinan elephant international trading co., LTD
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Email
13006575422@163.com
Beijing Jin Ming Biotechnology Co., Ltd.
Tel
010-60605840 18892239720
Email
psaitong@jm-bio.com
Amatek Scientific Co. Ltd.
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0512-56316828
Email
info@amateksci.com
Hangzhou HanLai Biochemical Technology Co., Ltd.
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571-86101219 18768477782
Email
sales09@leobiochem.com
Xi'an Confluore Biological Technology Co., Ltd.
Tel
+86-156-80926068 +86-15680926068
Email
1924344760@qq.com
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m-PEG11-acid(2280998-74-3)Related Product Information