m-PEG17-acid
m-PEG17-acid Basic information
- Product Name:
- m-PEG17-acid
- Synonyms:
-
- m-PEG17-acid
- mPEG16-CH2CH2COOH/2,5,8,11,14,17,20,23,26,29,32,35,38,41,44,47,50-Heptadecaoxatripentacontan-53-oic acid
- 2,5,8,11,14,17,20,23,26,29,32,35,38,41,44,47,50-Heptadecaoxatripentacontan-53-oic acid
- CAS:
- 2346581-96-0
- MF:
- C36H72O19
- MW:
- 808.95
- Mol File:
- 2346581-96-0.mol
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m-PEG17-acid Chemical Properties
- Boiling point:
- 763.8±60.0 °C(Predicted)
- Density
- 1.114±0.06 g/cm3(Predicted)
- form
- Solid
- pka
- 4.28±0.10(Predicted)
- color
- White to off-white
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m-PEG17-acid Usage And Synthesis
Biological Activity
m-PEG17-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References
[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
m-PEG17-acidSupplier
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