PEG6-(CH2CO2H)2 Chemical Properties

Boiling point:

524.8±45.0 °C(Predicted)

Density 

1.234±0.06 g/cm3(Predicted)

solubility 

Soluble in Water

pka

3.09±0.10(Predicted)

form 

Oil

color 

Light yellow to yellow

PEG6-(CH2CO2H)2 Usage And Synthesis

Description

PEG6-(CH2CO2H)2 is a PEG linker containing two terminal carboxylic acid groups. The hydrophilic PEG spacer increases solubility in aqueous media. The terminal carboxylic acids can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.

Uses

PEG6-(CH2CO2H)2 is a symmetric PEG PROTAC linker, for the synthesis of Homo-PROTACs which is bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation[1].

IC 50

PEGs

References

[1] Maniaci C, et al. Homo-PROTACs: bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation. Nat Commun. 2017 Oct 10;8(1):830. DOI:10.1038/s41467-017-00954-1

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