5-Methyluridine Chemical Properties

Melting point:

183-184 °C(lit.)

Density 

1.576±0.06 g/cm3(Predicted)

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

solubility 

Methanol (Slightly, Heated, Sonicated), Water (Sparingly, Sonicated)

pka

9.55±0.10(Predicted)

form 

powder

color 

white

PH

9.7

λmax

267 (pH 1)；268 (pH 13)

InChI

InChI=1S/C10H14N2O6/c1-4-2-12(10(17)11-8(4)16)9-7(15)6(14)5(3-13)18-9/h2,5-7,9,13-15H,3H2,1H3,(H,11,16,17)/t5-,6-,7-,9-/m1/s1

InChIKey

DWRXFEITVBNRMK-JXOAFFINSA-N

SMILES

OC[C@H]1O[C@@H](N2C=C(C)C(=O)NC2=O)[C@H](O)[C@@H]1O

CAS DataBase Reference

1463-10-1(CAS DataBase Reference)

Safety Information

Hazard Codes 

T+

Risk Statements 

26/27/28

Safety Statements 

24/25

WGK Germany 

3

HS Code 

29349990

MSDS

• Language:English Provider:SigmaAldrich

5-Methyluridine Usage And Synthesis

Description

5-Methyluridine is a pyrimidine nucleoside and methylated form of uridine. It is the ribonucleoside counterpart to the deoxyribonucleoside thymidine, which lacks a hydroxyl group at the 2' position. 5-Methyluridine contains a thymine base joined to a ribose pentose sugar. It is an endogenous methylated nucleoside found in human fluids. In cells, 5-methyluridine is present in tRNA, formed during its post-transcriptional modification by the methylation of uridine.

Chemical Properties

White Powder

Uses

A primary degradation product of tRNA, an urinary nucleoside as biological marker for patients with colorectal cancer.
It enhances the antitumor activity of 5-fluorouracil in a mouse Erlich solid carcinoma model and a P388 murine leukemia model. It has been used to characterize the activity of a variety of enzymes, including uridine nucleosidase.

Definition

ChEBI: Ribothymidine is a methyluridine having a single methyl substituent at the 5-position on the uracil ring. It has a role as a human metabolite, an Escherichia coli metabolite and an antigen.

5-Methyluridine(1463-10-1)Related Product Information

• 5-Methyluridine
• 2,2'β-Oxy-2-deoxo-2,3-didehydro-2'-deoxy-5-methyluridine,2,2'-ANHYDRO-5-METHYLURIDINE,O2,2'-Anhydro-5-methyluridine
• 2'-DEOXY-2'-FLUORO-5-METHYLURIDINE
• DMT-2'O-Methyl-rU Phosphoramidite
• 2'-C-Methyluridine
• 2'-O-METHYL-5-METHYLURIDINE,5-METHY-5-METHYLURIDINE
• 2'-O-METHYLURIDINE,2''-O-METHYLURIDINE CRYSTALLINE
• 3-METHYLURIDINE
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• THYMIDINE 5'-MONOPHOSPHATE, [2-14C] DISODIUM SALT
• (AA-UTP) SODIUM SALT
• 5-METHYL-[1'-13C]URIDINE
• HT MEDIA SUPPLEMENT
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• 5'-O-(DIMETHOXYTRITYL)-2'-O-METHYL-5-METHYLURIDINE
• FLUORESCEIN-12-UTP
• 5-formyloxymethyluridine
• THYMIDINE-3',5'-DIPHOSPHATE, DISODIUM SALT