4-AMINO-PYRIDIN-2-OL Chemical Properties

Melting point:

219-221 °C(Solv: acetone (67-64-1))

Boiling point:

310.7±35.0 °C(Predicted)

Density 

1.208±0.06 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2–8 °C

form 

solid

pka

11.49±0.10(Predicted)

Appearance

White to light brown Solid

CAS DataBase Reference

38767-72-5

Safety Information

Hazard Codes 

Xn

Risk Statements 

22

HS Code 

2933399990

4-AMINO-PYRIDIN-2-OL Usage And Synthesis

Uses

4-Amino-2-pyridone is used in the preparation of nucleoside analogues with antitumor and antiviral activity.

Synthesis

General procedure for the synthesis of 4-aminopyridin-2-one from 2-chloro-4-aminopyridine: A mixture of 2-chloro-4-aminopyridine (127 mg, 1.0 mmol) and potassium hydroxide (280.6 mg, 5.0 mmol) in toluene (4.0 mL) was heated in a sealed tube and reacted for 72 hr at 170 °C. Upon completion of the reaction, the mixture was cooled to room temperature and the toluene solvent was subsequently removed by distillation under reduced pressure. The residue was purified by rapid chromatography on silica gel (eluent ratio dichloromethane/methanol/ammonia: 78/20/2) to afford the target product 4-aminopyridin-2-one (107 mg, 97% yield) as a light yellow solid.

References

[1] Synlett, 2016, vol. 27, # 1, p. 67 - 69
[2] Tetrahedron, 1999, vol. 55, # 41, p. 11985 - 11996

4-AMINO-PYRIDIN-2-OL(38767-72-5)Related Product Information

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• 2-AMINO-PYRIDIN-3-OL,2-AMINO-3-HYDROXYPYRIDINE 2-AMINO-PYRIDIN-3-OL
• 3,4-Diamino-2-hydroxypyridine
• 4,5-DIAMINO-6-HYDROXYPYRIMIDINE SULFATE
• 5,6-DICHLORONICOTINIC ACID ETHYL ESTER
• 5-AMINO-PYRIDIN-2-OL
• 6-AMINO-PYRIDIN-3-OL,6-Amino-pyridin-3-ol hydrobromide
• 6-AMINO-PYRIDIN-2-OL
• 3-AMINO-PYRIDIN-2-OL
• 6-AMINO-PYRIDIN-3-OL HYDROCHLORIDE
• 2-AMINO-PYRIDIN-4-OL
• 4,5-Diamino-2-pyridinol
• 4-AMINO-PYRIDIN-3-OL,4-Amino-pyridin-3-ol HBr
• 3-Amino-2(1H)-pyridinone
• Fluroxypyr
• 4-Amino-2-ethoxypyridine
• Starane
• 3-Amino-4-pyridinol