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Adenine

Basic information Safety Supplier Related

Adenine Basic information

Product Name:
Adenine
Synonyms:
  • Adenin
  • Adeninimine
  • Leuco-4
  • Purine, 6-amino-
  • USAF CB-18
  • usafcb-18
  • vitaminb4(adenine)
  • ADENINE FREE BASE PLANT TISSUE CULTURETE STED
CAS:
73-24-5
MF:
C5H5N5
MW:
135.13
EINECS:
200-796-1
Product Categories:
  • Nucleobases and their analogs
  • Plant Growth Regulators
  • Biochemistry
  • Cytokinins
  • Nucleosides, Nucleotides & Related Reagents
  • Nutritional Supplements
  • Nucleic acids
  • Vitamin Ingredients
  • Nucleic acid purification
  • PLANT GROWTH REGULATOR
  • Purines
  • PYRIMIDINE
  • Pharmaceutical Intermediates
  • vitamin series
  • Pyridines ,Halogenated Heterocycles
  • Inhibitors
  • Amines
  • Bases & Related Reagents
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Nucleotides
  • Pharmaceuticals
  • Other Products
  • MONACRIN
  • nucleoside
Mol File:
73-24-5.mol
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Adenine Chemical Properties

Melting point:
>360 °C(lit.)
Boiling point:
238.81°C (rough estimate)
Density 
1.3795 (rough estimate)
refractive index 
1.7000 (estimate)
Flash point:
220°C
storage temp. 
Store at RT.
solubility 
0.5 M HCl: soluble20mg/mL, Grade III, colorless to faint yellow or tan
form 
Liquid or Solid
pka
4.12(at 25℃)
color 
Clear colorless to light yellow
Odor
Odorless
PH Range
7
Water Solubility 
0.5 g/L (20 ºC)
Merck 
14,152
Sublimation 
220 ºC
BRN 
5777
Stability:
Stable. Moisture-sensitive. Incompatible with strong oxidizing agents.
InChIKey
GFFGJBXGBJISGV-UHFFFAOYSA-N
CAS DataBase Reference
73-24-5(CAS DataBase Reference)
NIST Chemistry Reference
Adenine(73-24-5)
EPA Substance Registry System
Adenine (73-24-5)
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Safety Information

Hazard Codes 
Xn,Xi
Risk Statements 
22-20/21/22
Safety Statements 
26-36
RIDADR 
UN 2811 6.1/PG 3
WGK Germany 
3
RTECS 
AU6125000
8-10-23
TSCA 
Yes
HazardClass 
6.1
PackingGroup 
III
HS Code 
29335990
Toxicity
LD50 orally in rats: 745 mg/kg (Philips)

MSDS

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Adenine Usage And Synthesis

Description

adenine is one of the purine nitrogenous bases that composes DNA and RNA; composed of two carbon–nitrogen rings. Adenine bonds with thymine in DNA and with uracil in RNA (see base pairing rule); it is also a major component of other molecules such as adenosine triphosphate.

Chemical Properties

White to almost white crystalline powder

Chemical Properties

Adenine is a prominent member of the family of naturally occurring purines. Adenine occurs not only in ribonucleic acids (RNA), and deoxyribonucleic acids (DNA), but in nucleosides, such as adenosine, and nucleotides, such as adenylic acid, which may be linked with enzymatic functions quite apart from nucleic acids. Adenine, in the form of its ribonucleotide, is produced in mammals and fowls endogenously from smaller molecules and no nutritional essentiality is ascribed to it. In the nucleosides, nucleotides, and nucleic acids, the attachment or the sugar moiety is at position 9.
The purines and pyrimidines absorb ultraviolet light readily, with absorption peaks at characteristic frequencies. This has aided in their identification and quantitative determination.

Physical properties

Adenine is a white crystalline substance that is an important biological compound found in deoxyribonucleic acid (DNA), ribonucleic acid (RNA), and adenosine triphosphate (ATP). It was once commonly referred to as vitamin B4 but is no longer considered a vitamin. Adenine is derived from purine. Purine is a heterocyclic compound.

History

Adenine is one of the two purines found in DNA and RNA. The other is guanine. Adenine and guanine are called bases in reference to DNA and RNA. A nucleic acid base attached to ribose forms a ribonucleoside. Adenine combined with ribose produces the nucleoside adenosine.

Uses

local antiseptic

Uses

Vitamin B4

Uses

Widespread throughout animal and plant tissues combined with niacinamide, d-ribose, and phosphoric acids; a constituent of nucleic acids and coenzymes, such as codehydrase I and II, adenylic acid, coa laninedehydrase. It is used in microbial determination of niacin; in research on heredity, virus diseases, and cancer.

Uses

enteric coating

Uses

A purine nucleobase and a component of DNA

Definition

A nitrogenous base found in DNA and RNA. It is also a constituent of certain coenzymes and when combined with the sugar ribose it forms the nucleoside adenosine found in AMP, ADP, and ATP. Adenine has a purine ring structure.

Definition

adenine: A purine derivative. It isone of the major component bases ofnucleotides and the nucleic acidsDNA and RNA.

Definition

ChEBI: The parent compound of the 6-aminopurines, composed of a purine having an amino group at C-6.

Synthesis Reference(s)

Journal of the American Chemical Society, 88, p. 3829, 1966 DOI: 10.1021/ja00968a028

Safety Profile

Poison by intraperitoneal route. Moderately toxic by ingestion. An experimental teratogen. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx,.

Purification Methods

Crystallise adenine from distilled water. [Beilstein 26 III/IV 3561.]

AdenineSupplier

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