H-GLU(OBZL)-OBZL HCL Chemical Properties

Melting point:

102.0 to 106.0 °C

RTECS 

MA0885000

storage temp. 

Inert atmosphere,Room Temperature

solubility 

Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.

form 

Powder

color 

White

CAS DataBase Reference

4561-10-8

Safety Information

HS Code 

2922498590

H-GLU(OBZL)-OBZL HCL Usage And Synthesis

Uses

L-Glutamic acid dibenzyl ester hydrochloride oxalate used as a intermediate in pharmaceutical and chemical synthesis. Also used in medicine research.

Uses

H-Glu(Obzl)-Obzl HCl

Synthesis

To a 500 mL four-necked flask equipped with a mechanical stirrer, a thermometer and a reflux condenser tube (connected to a 30% aqueous sodium hydroxide solution absorption unit) were sequentially added 280 g of benzyl alcohol, 14.7 g (0.10 mol) of L-glutamic acid and 30.0 g (0.25 mol) of thionyl chloride. The reaction mixture was heated to 80-85 °C and the reaction was stirred at this temperature for 5 hours. Upon completion of the reaction, the reaction solution was cooled to 20-25 °C and nitrogen was passed to displace the hydrogen chloride gas in the system for 30 min. Subsequently, excess thionyl chloride and benzyl alcohol were recovered by distillation. To the residue, 120 mL of methyl tert-butyl ether was added for pulping treatment, and the solid product was collected by filtration and dried to give 35.9 g of white solid L-glutamic acid dibenzyl ester hydrochloride, which was analyzed by liquid chromatography to have a purity of 99.8% and a yield of 98.7%.

References

[1] Patent: CN107602436, 2018, A. Location in patent: Paragraph 0047; 0048; 0049; 0050
[2] Journal of the Chinese Chemical Society, 2009, vol. 56, # 5, p. 1010 - 1017
[3] Bioorganic and Medicinal Chemistry, 2010, vol. 18, # 17, p. 6220 - 6229

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