2-IODO-3-HYDROXYPYRIDINE Chemical Properties

Melting point:

193-195°C

Boiling point:

296.6±20.0 °C(Predicted)

Density 

2.142±0.06 g/cm3(Predicted)

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

pka

4.74±0.10(Predicted)

form 

Crystalline Powder

color 

White to tan

Water Solubility 

Slightly soluble in water.

Sensitive 

Light Sensitive

BRN 

109836

InChI

InChI=1S/C5H4INO/c6-5-4(8)2-1-3-7-5/h1-3,8H

InChIKey

HJBGMPCMSWJZNH-UHFFFAOYSA-N

SMILES

C1(I)=NC=CC=C1O

CAS DataBase Reference

40263-57-8(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xn

Risk Statements 

36/37/38-41-37/38-22

Safety Statements 

26-36-39

WGK Germany 

3

HazardClass 

IRRITANT

HS Code 

2933399990

MSDS

• Language:English Provider:ALFA

2-IODO-3-HYDROXYPYRIDINE Usage And Synthesis

Uses

2-Iodo-3-hydroxypyridine acts as a reagent in the synthesis of the differentiating antibiotic azatyrosine

Synthesis

General procedure for the synthesis of 2-iodo-3-hydroxypyridine using 3-hydroxypyridine as starting material: sodium carbonate (Na2CO3, 11.6 g, 109.72 mmol) and iodine (I2, 13.3 g, 52.57 mmol) were added sequentially to a solution of 3-hydroxypyridine (5.0 g, 52.57 mmol) in water (400 mL). The reaction mixture was stirred at room temperature for 2 hours. After completion of the reaction, the pH was adjusted to 4 with 1 M hydrochloric acid (HCl) solution. the precipitate was collected by filtration, washed with cold water and dried to give 2-iodo-3-hydroxypyridine (10.7 g, 92% yield) as a white powder. The product characterization data were as follows: melting point 189-190 °C (neat); thin layer chromatography (TLC) Rf = 0.33 (unfolding reagent dichloromethane/ethanol, 97/3, v/v); infrared spectroscopy (IR, KBr pressed) νmax (cm-1): 2851, 2722, 2573, 2345, 1560, 1455, 1301, 1189, 1121, 794, 668; nuclear magnetic resonance hydrogen spectrum (1H NMR, 400 MHz, DMSO-d6): δ10.88 (s, 1H, OH), 7.87 (dd, 1H, J1 = 1.6 Hz, J2 = 4.4 Hz, H-6), 7.24 (dd, 1H, J1 = 4.4 Hz, J2 = 8.0 Hz, H-5), 7.18 (dd, 1H, J1 = 1.6 Hz, J2 = 8.0 Hz, H-4); nuclear magnetic resonance carbon spectrum (13C NMR, 100 MHz, DMSO-d6): δ 154.0, 141.8, 124.3, 121.3, 110.9; high resolution mass spectrometry (HRMS) calculated value of C5H4INO [M + H]+ 221.9410, measured value 221.9416.

References

[1] Tetrahedron Letters, 2012, vol. 53, # 8, p. 944 - 947
[2] Tetrahedron, 2017, vol. 73, # 41, p. 6000 - 6007
[3] Patent: CN107793420, 2018, A. Location in patent: Paragraph 0009
[4] Roczniki Chemii, 1936, vol. 16, p. 502,507
[5] Chem. Zentralbl., 1937, vol. 108, # I, p. 3634

2-IODO-3-HYDROXYPYRIDINE(40263-57-8)Related Product Information

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• 4-Iodo-2-hydroxypyridine
• 4-IODO-3-HYDROXYPYRIDINE
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