4'-HYDROXY-2'-METHYLACETOPHENONE Chemical Properties

Melting point:

129-131 °C(lit.)

Boiling point:

313 °C(lit.)

Density 

1.059 g/mL at 25 °C(lit.)

refractive index 

1.5369 (estimate)

storage temp. 

Inert atmosphere,Room Temperature

solubility 

soluble in Methanol

pka

8.28±0.18(Predicted)

form 

Powder or Crystals

color 

Off-white to beige to tan

Specific Gravity

1.059

LogP

1.884 (est)

CAS DataBase Reference

875-59-2(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-37/39-36

WGK Germany 

3

HS Code 

29145090

MSDS

• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich

4'-HYDROXY-2'-METHYLACETOPHENONE Usage And Synthesis

Chemical Properties

off-white to beige crystalline powder

Uses

4''-Hydroxy-2''-methylacetophenone has been used in the preparation of morpholine ketone analogs as potent histamine H3 receptor inverse agonists with wake activity.

Definition

ChEBI: A member of the class of acetophenones that is acetophenone substituted by a hydroxy group at position 4 and a methyl group at position 2 respectively.

Preparation

Preparation by dealkylation of 4-hydroxy-2-methyl-5-iso-propylacetophenone with aluminium chloride in chlorobenzene at 50° (80%).

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