2,4-DICHLORO-6-METHOXYQUINOLINE Chemical Properties

Boiling point:

327.9±37.0 °C(Predicted)

Density 

1.384±0.06 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

pka

-1.09±0.50(Predicted)

Appearance

Light yellow to yellow Solid

Safety Information

HS Code 

2933499090

2,4-DICHLORO-6-METHOXYQUINOLINE Usage And Synthesis

Synthesis Reference(s)

Synthesis, p. 623, 1993 DOI: 10.1055/s-1993-25914

Synthesis

1. In a 3-necked round-bottomed flask fitted with a condenser and a room temperature stirring bar, phosphorus (V) chloride oxide (40 mL, 1.5 M) and malonic acid (6.244 g, 60.00 mmol) were added. 2. p-Aminoanisole (9.236 g, 75.00 mmol) was added in small portions over 15 minutes under stirring conditions through an open neck portion of the round bottom flask. 3. The reaction mixture was heated to reflux and stirred continuously for 5 hours. 4. Upon completion of the reaction, the mixture was cooled to room temperature and then slowly poured into crushed ice (700 mL). 5. The pH of the resulting aqueous solution was adjusted to 10 with concentrated ammonium hydroxide (85 mL). 6. The aqueous phase was extracted using dichloromethane and the organic layers were combined. 7. The organic layer was dried over anhydrous magnesium sulfate and subsequently concentrated under reduced pressure. 8. The crude product was purified by column chromatography (eluent: 0-5% hexane solution of ethyl acetate) to afford 2,4-dichloro-6-methoxyquinoline as a pale yellow solid (4.7812 g, 35% yield). 9. Characterization of the product: melting point 170.5-171.5 °C; thin-layer chromatography (TLC) Rf = 0.27 (2% ethyl acetate/hexane); infrared spectroscopy (thin-film) νmax 3084, 3013, 2982, 1623, 1562, 1499 cm-1; 1H NMR (500 MHz, CDCl3) δ 7.90 (d, J = 9.0 Hz, 1H), 7.45 (s, 1H), 7.5 (s, 1H). , 7.45 (s, 1H), 7.40 (dd, J = 9.0, 3.0 Hz, 1H), 7.36 (d, J = 3.0 Hz, 1H), 3.96 (s, 3H); 13C NMR (125 MHz, CDCl3) δ 158.9, 147.0, 144.0, 142.6, 130.4, 126.3, 124.1, 122.0, 101.9, 55.7; high-resolution mass spectrometry data have been submitted.

References

[1] Heterocyclic Communications, 2001, vol. 7, # 4, p. 353 - 358
[2] Research on Chemical Intermediates, 2014, vol. 40, # 5, p. 1851 - 1866
[3] Medicinal Chemistry, 2015, vol. 11, # 8, p. 789 - 797
[4] Patent: US2012/88915, 2012, A1. Location in patent: Page/Page column 14
[5] Chemistry of Heterocyclic Compounds, 2015, vol. 51, # 3, p. 250 - 258

2,4-DICHLORO-6-METHOXYQUINOLINE(70049-46-6)Related Product Information

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