PYRAZOLO[1,5-A]PYRIMIDINE-3-CARBOXYLIC ACID Chemical Properties

Melting point:

180°C

Density 

1.58±0.1 g/cm3(Predicted)

storage temp. 

2-8°C

pka

-1.71±0.41(Predicted)

form 

solid

Appearance

Yellow to brown Solid

Water Solubility 

Soluble in water

InChI

InChI=1S/C7H5N3O2/c11-7(12)5-4-9-10-3-1-2-8-6(5)10/h1-4H,(H,11,12)

InChIKey

HNYVPKNVKSTVJO-UHFFFAOYSA-N

SMILES

C12=C(C(O)=O)C=NN1C=CC=N2

CAS DataBase Reference

25940-35-6(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi,Xn

Risk Statements 

36/37/38-22

Safety Statements 

26-36

WGK Germany 

3

HazardClass 

IRRITANT

HS Code 

2916399090

MSDS

• Language:English Provider:ALFA

PYRAZOLO[1,5-A]PYRIMIDINE-3-CARBOXYLIC ACID Usage And Synthesis

Uses

Pyrazolo[1,5-a]pyrimidine-3-carboxylic acid, is used as a chemicals, pharmaceutical intermediates, reagents. It is an important raw material and intermediate used in pharmaceuticals, agro based and dye stuff fields.

Synthesis

The general procedure for the synthesis of pyrazolo[1,5-a]pyrimidine-3-carboxylic acid from ethyl pyrazolo[1,5-a]pyrimidine-3-carboxylate was as follows: to a mixture of ethyl pyrazolo[1,5-a]pyrimidine-3-carboxylate (3.15 g, 16.4 mmol) in ethanol (50 mL) and water (40 mL) was added an aqueous solution of 2 M potassium hydroxide (40 mL). The reaction mixture was stirred at 50 °C for 2 h, subsequently cooled to room temperature and concentrated under vacuum. The resulting mixture was adjusted to pH=2 with 1 M aqueous hydrochloric acid, at which time a white solid precipitated. The white solid product was collected by filtration to give 2.6 g (97% yield). The product was detected by LC-MS (ESI, negative ion mode), m/z: 162.1 [M-H]-. 1H NMR (600 MHz, DMSO-d6) δ (ppm): 9.26 (dd, J=7.0,1.7 Hz, 1H), 8.80 (dd, J=4.1,1.7 Hz, 1H), 8.58 (s, 1H), 7.26 ( dd, J=7.0,4.1 Hz, 1H).

References

[1] Patent: WO2015/73267, 2015, A1. Location in patent: Paragraph 390
[2] Patent: CN104650092, 2017, B. Location in patent: Paragraph 0770-0771; 0776-0777

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