ALPHA-BUNGAROTOXIN
ALPHA-BUNGAROTOXIN Basic information
- Product Name:
- ALPHA-BUNGAROTOXIN
- Synonyms:
-
- ALPHA-BUNGAROTOXIN
- ALPHA-BUNGAROTOXIN, BUNGARUS MULTICINCTUS
- ALPHA-BUTX
- ALPHA-BGT
- A-BUNGAROTOXIN
- M.W. 7984.14 C338H529N97O105S11
- H-ILE-VAL-CYS-HIS-THR-THR-ALA-THR-SER-PRO-ILE-SER-ALA-VAL-THR-CYS-PRO-PRO-GLY-GLU-ASN-LEU-CYS-TYR-ARG-LYS-MET-TRP-CYS-ASP-ALA-PHE-CYS-SER-SER-ARG-GLY-LYS-VAL-VAL-GLU-LEU-GLY-CYS-ALA-ALA-THR-CYS-PRO-SER-LYS-LYS-PRO-TYR-GLU-GLU-VAL-THR-CYS-CYS-SER-THR-ASP-LYS-CYS-ASN-PRO-HIS-PRO-LYS-GLN-ARG-PRO-GLY-OH
- BUNGARUS MULTICINCTUS TOXIN, ALPHA
- CAS:
- 11032-79-4
- MF:
- C50H70O14
- MW:
- 895.0824
- EINECS:
- 234-266-6
- Product Categories:
-
- Acetylcholine receptor
- Mol File:
- 11032-79-4.mol
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ALPHA-BUNGAROTOXIN Chemical Properties
- storage temp.
- −20°C
- solubility
- Soluble in sterile water
- form
- solid
- color
- white
- Water Solubility
- Soluble in water
- CAS DataBase Reference
- 11032-79-4
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MSDS
- Language:English Provider:SigmaAldrich
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ALPHA-BUNGAROTOXIN Usage And Synthesis
Chemical Properties
Single polypeptide weight; molecular weight of 8000.
Definition
A protein that binds specifically to acetylcholine receptors.
General Description
Blocks neuromuscular transmission by irreversible binding to motor end-plate acetylcholine receptor (Kd = 1 pM to 1 nM) but does not depress acetylcholine release from motor nerve endings. Blocks nicotine-induced increase of intracellular Ca2+ in PC12 cells (IC50 = 310 nM), and prevents opening of nicotinic receptor-associated ion channels. Reconstitution experiments in Xenopus oocytes have shown the effects of α-bungarotoxin on neuronal nAChR to be highly specific for the α7-subtype (IC50 = 1.6 nM), but not for the α3β4-subtype (IC50 >3 μM).
Hazard
Nuerotoxic.
Biochem/physiol Actions
Product does not compete with ATP.
storage
-20°C (desiccate)
ALPHA-BUNGAROTOXINSupplier
3B Pharmachem (Wuhan) International Co.,Ltd.
- Tel
- 821-50328103-801 18930552037
- 3bsc@sina.com
Shenzhen Regent Biochemical Technology Co., Ltd.
- Tel
- 0755-0755-85201366 18938635012
- sales@regentsciences.com
Hangzhou Peptidego Biotech Co.,Ltd.
- Tel
- 0571-87213919
- eric@peptidego.com
Dayang Chem (Hangzhou) Co.,Ltd.
- Tel
- 571-88938639 +8617705817739
- info@dycnchem.com
AFINE CHEMICALS LIMITED
- Tel
- 0571-85134551
- info@afinechem.com
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ALPHA-BUNGAROTOXIN(11032-79-4)Related Product Information
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