Fleroxacin Chemical Properties

Melting point:

264-266°C

Boiling point:

535.3±50.0 °C(Predicted)

Density 

1.409±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

solubility 

0.1 M NaOH: soluble10mg/mL

form 

solid

pka

-0.54±0.20(Predicted)

color 

white to off-white

Merck 

14,4099

CAS DataBase Reference

79660-72-3(CAS DataBase Reference)

Safety Information

WGK Germany 

2

RTECS 

VB1999050

HS Code 

29335990

Fleroxacin Usage And Synthesis

Description

Fleroxacin is a new, once daily trifluoroquinolone antibacterial structurally related to norfloxacin. Available in both oral and IV formulations, it is reportedly useful in the treatment of gonorrhea, bacterial enteritis, chronic bronchitis and urinary tract infections. Fleroxacin has a longer serum half-life (9-12 hours) than other drugs of this class, such as ciprofloxacin, enoxacin and norfloxacin.

Chemical Properties

White Needle-Like Crystals

Originator

Kyorin (Japan)

Uses

An antibacterial.

Uses

antibiotic

Definition

ChEBI: A fluoroquinolone antibiotic that is 4-oxo-1,4-dihydroquinoline which is substituted at positions 1, 3, 6, 7 and 8 by 2-fluoroethyl, carboxy, fluoro, 4-methylpiperazin-1-yl and fluoro groups, respectively. It is active against many Gram-positive and Gram-n gative bacteria.

Manufacturing Process

6,8-Difluoro-1-(2-fluoroethyl)-1,4-dihydro-7-(4-methyl-1-piperazinyl)-4- oxoquinoline-3-carboxylic acid hydrochloride:
A mixed solution of 1-methylpiperazine (0.34 g) and pyridine (3 ml) was added to 6,7,8-trifluoro-1-(2-fluoroethyl)-1,4-dihydro-4-oxoquinoline-3- carboxylic acid (0.12 g) and heated to reflux for 6 hours. After the solvent evaporated and cooled, the residue was adjusted to pH 1 with aqueous hydrochloric acid. The cooled mixture was filtered off and the solid recrystallized from water to give 6,8-difluoro-1-(2-fluoroethyl)-1,4-dihydro-7- (4-methyl-1-piperazinyl)-4-oxoquinoline-3-carboxylic acid hydrochloride (0.08 g), melting point 269-271°C (decomp.).

brand name

Quinodis

Therapeutic Function

Antibacterial

Fleroxacin(79660-72-3)Related Product Information

• (2-Methoxyethyl)benzene
• 1-Methylpiperazine
• DL-α-Tocopherol
• N-Aminoethylpiperazine
• Diphenolic acid
• 4-(Diethylamino)salicylaldehyde
• 5-Chlorovaleric acid
• Pralmorelin
• Methyl 2-hydroxyethyl cellulose
• Dihydromyrcenol
• 2-Butanone
• 4-AMINO-3,5-DIFLUOROACETOPHENONE
• 3-(4-Methylpiperazin-1-yl)aniline
• Pefloxacin
• FLEROXACINLACTATE
• Norfloxacin
• 8-FLUORO-4(1H)-QUINOLINONE
• Benzenamine, 3-(1-piperazinyl)- (9CI)