2-(4-Methylphenyl)propanoic acid Chemical Properties

Melting point:

37-42 °C(lit.)

Boiling point:

231.67°C (rough estimate)

Density 

1.0041 (rough estimate)

refractive index 

1.518-1.52

Flash point:

>230 °F

storage temp. 

Sealed in dry,Room Temperature

solubility 

Chloroform (Slightly), Methanol (Slightly)

form 

Solid

pka

4.44±0.10(Predicted)

color 

White to Off-White

BRN 

2251315

CAS DataBase Reference

938-94-3(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

WGK Germany 

3

HS Code 

29163990

MSDS

• Language:English Provider:2-(4-Tolyl)propionic acid
• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich

2-(4-Methylphenyl)propanoic acid Usage And Synthesis

Chemical Properties

clear yellow liquid after melting

Uses

2-(p-Tolyl)propionic acid (Ibuprofen EP Impurity D) is an impurity of Ibuprofen (I140000). Ibuprofen impurity D.

Uses

2-(p-Tolyl)propionic acid is an impurity of Ibuprofen (I140000). Ibuprofen impurity D.

Synthesis Reference(s)

Synthesis, p. 231, 1984 DOI: 10.1055/s-1984-30784
Tetrahedron Letters, 36, p. 5641, 1995 DOI: 10.1016/0040-4039(95)01035-G

General Description

α,4-Dimethylphenylacetic acid is also referred to as 2-(4-methylphenyl)propanoic acid. It is an alkaline decomposition product of azalomycin-B, a macrolide antibiotic produced by Streptomyces hygroscopicus var. azalomyceticus. The reaction of pinonic acid with bromine in water affords 2-(4-methylphenyl)propanoic acid.

2-(4-Methylphenyl)propanoic acid(938-94-3)Related Product Information

• Propionic acid
• METHYLSTYRENE
• Silicone oil (high temperature)
• 2,3-Dibromopropionic acid
• Chlorodimethylphenylsilane
• Propionic anhydride
• 2-Chloropropionic acid
• DL-Phenylalanine
• (S)-(+)-2-Phenylpropionic acid
• 1-Methyl-4-(methylsulfonyl)-benzene
• 2,2-Bis(hydroxymethyl)propionic acid
• IBUPROFEN IMP. D (EP): 2-(4-METHYLPHENYL)PROPANOIC ACID MM(CRM STANDARD)
• (S)-(+)-Ibuprofen
• Z-AIB-OH
• (R)-(-)-IBUPROFEN
• 1-Hydroxyibuprofen
• 1-Oxo Ibuprofen
• Ibuprofen Ethyl Ester