ANGIOTENSIN III, HUMAN Chemical Properties

Density 

1.39±0.1 g/cm3(Predicted)

storage temp. 

−20°C

solubility 

H₂O: 1.0 mg/mL, clear, colorless

form 

Lyophilized.

pka

3.56±0.10(Predicted)

color 

White to off-white

Sequence

Arg-Val-Tyr-Ile-His-Pro-Phe

Safety Information

WGK Germany 

3

F 

10

MSDS

• Language:English Provider:SigmaAldrich

ANGIOTENSIN III, HUMAN Usage And Synthesis

Description

Angiotensin III (Ang III) is a heptapeptide agonist at the angiotensin 1 (AT₁) and AT₂ receptors, with a 30-fold higher affinity for AT₂ compared with AT₁ in HEK293 cells. Ang III is the preferred agonist for renal AT₂ receptors, which are responsible for sodium excretion into the urine. Ang III induces the same level of aldosterone synthesis as Ang II but has lower vasoconstrictive activity in vivo. In the brain renin-angiotensin system, Ang III increases sympathetic nerve activity and vasopressin release and dampens the baroreflex leading to higher blood pressure.

Uses

Angiotensin III, human, mouse is a heptapeptide, acts as an endogenous angiotensin type 2 receptor (AT2R) agonist, with IC50s of 0.648 nM and 21.1 nM for AT2R and AT1R, respectively.

Definition

ChEBI: Angiotensin III is a peptide.

in vivo

IC 50

AT2 Receptor

References

[1] Bosnyak S, et al. Relative affinity of angiotensin peptides and novel ligands at AT1 and AT2 receptors. Clin Sci (Lond). 2011 Oct;121(7):297-303. DOI:10.1042/CS20110036
[2] Kemp BA, et al. Intrarenal angiotensin III is the predominant agonist for proximal tubule angiotensin type 2 receptors. Hypertension. 2012 Aug;60(2):387-95. DOI:10.1161/HYPERTENSIONAHA.112.191403
[3] Gao J, et al. A new strategy for treating hypertension by blocking the activity of the brain renin-angiotensin system with aminopeptidase A inhibitors. Clin Sci (Lond). 2014 Aug;127(3):135-48. DOI:10.1042/CS20130396

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