GLUCAGON-LIKE PEPTIDE I FRAGMENT 7-36 AMIDE HUMAN Chemical Properties

Density 

1.47

RTECS 

LZ3980060

storage temp. 

−20°C

solubility 

Soluble in DMSO

form 

powder

Water Solubility 

Soluble in water (1 mg/ml).

InChIKey

DTHNMHAUYICORS-KTKZVXAJSA-N

Safety Information

WGK Germany 

3

MSDS

• Language:English Provider:SigmaAldrich

GLUCAGON-LIKE PEPTIDE I FRAGMENT 7-36 AMIDE HUMAN Usage And Synthesis

Uses

Diabetes?II?-?not?yet?an?approved?application

Uses

Glucagon-Like Peptide-1 is used as a Effector in the hormonal control of insulin secretion. The peptide fragment is secreted from the lower small intestine. Its action is mediated by receptors expressed by the endocrine pancreatic B-cells.

Uses

Glucagon-Like Peptide (GLP) I Amide Fragment 7-36 human has been used as a GLP-1 receptor agonist:

• in lysate transfer cyclic adenosine monophosphate (cAMP) assay to test its effect on adenylyl cyclase activity
• to pre-treat the human umbilical vein endothelial cells (HUVECs) to monitor its effect on hyperpermeability in endothelial cell (EC) monolayers and changes with the actin cytoskeleton
• to test its inhibitory effect on vascular endothelial growth factor-A (VEGFA) based vasodilation in rat mesenteric arteries

General Description

Glucagon-like peptide 1 (GLP-1) peptide is obtained from proglucagon and is metabolically inactive. However, it is processed to two smaller amide forms, namely GLP-1 (7-37) amide and GLP-1 (7-36) amide. It is a natural gastrointestinal peptide.

Biochem/physiol Actions

GLP-1 (glucagon-like peptide 1) (7-36) amide is a potent insulinotropic peptide, which initiates the glucose-induced insulin release after meals or oral glucose intake. It has an anti-diabetogenic effect and thus, might have use in the treatment of non-insulin dependent diabetes mellitus.

storage

Store at -20°C

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