2-Amino-5-chlorobenzophenone Chemical Properties

Melting point:

96-98 °C (lit.)

Boiling point:

207 °C

Density 

1.33

vapor pressure 

0-1Pa at 20-25℃

refractive index 

1.6000 (estimate)

Flash point:

211 °C

storage temp. 

Store below +30°C.

solubility 

Solubility in methanol gives very faint turbidity. Soluble in DMSO.

pka

0.06±0.10(Predicted)

form 

Crystalline Powder

color 

Yellow

BRN 

475640

Stability:

Stable. Incompatible with strong oxidizing agents.

InChIKey

ZUWXHHBROGLWNH-UHFFFAOYSA-N

LogP

3.16 at 21℃ and pH7

CAS DataBase Reference

719-59-5(CAS DataBase Reference)

NIST Chemistry Reference

Benzophenone, 2-amino-5-chloro-(719-59-5)

EPA Substance Registry System

Methanone, (2-amino-5-chlorophenyl)phenyl- (719-59-5)

Safety Information

Hazard Codes 

Xi,Xn

Risk Statements 

36/37/38-22-20/21/22

Safety Statements 

26-36

WGK Germany 

3

RTECS 

PC4933500

TSCA 

Yes

HS Code 

29223900

Toxicity

LD50 orally in Rabbit: 10000 mg/kg

MSDS

• Language:English Provider:5-Chloro-2-aminobenzophenone
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

2-Amino-5-chlorobenzophenone Usage And Synthesis

Chemical Properties

yellow powder

Uses

A metabolite of Diazepam; it had a much weaker anticonvulsant effect.

Uses

It is used in the heterocyclic syntheses based on the reactions of dimethyl acetylenedicarboxylate.

Synthesis Reference(s)

Tetrahedron Letters, 35, p. 6811, 1994 DOI: 10.1016/0040-4039(94)85011-9

General Description

2-Amino-5-chlorobenzophenone is a organic nonlinear optical material.

Synthesis

(2) 10.0 g of intermediate (II) was added to a three-necked flask containing 50 mL of ethanol, 4.8 g of iron powder was added, and refluxed for 0.5 hours. Subsequently, 1 mL of 6 mol/L sulfuric acid solution was slowly added dropwise. After the dropwise addition, the reaction was continued to reflux for 1 hour. After the reaction was completed, the pH of the reaction solution was adjusted to 8 with NaOH solution and cooled to 50 °C. Add 0.2 g of activated carbon and reflux for 0.5 h. Perform hot filtration into a crystallization flask and cool the crystals. The crystals were washed with ethanol and dried to give 9.60 g of intermediate (III) in 95.1% yield, melting point 96.3-98.2 °C.

References

[1] Journal of Chemical Research - Part S, 2002, # 12, p. 601 - 603
[2] Patent: CN108250091, 2018, A. Location in patent: Paragraph 0032; 0034; 0040
[3] Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1994, vol. 33, # 7, p. 690 - 691
[4] Patent: CN106083621, 2016, A. Location in patent: Paragraph 0021-0025
[5] Patent: CN107935872, 2018, A. Location in patent: Paragraph 0034-0063; 0067-0074

2-Amino-5-chlorobenzophenone(719-59-5)Related Product Information

• Benzophenone
• Phenylhydrazine
• ALTRENOGEST
• 2-Aminobenzophenone
• Betaine
• (3,4-Diaminophenyl)phenylmethanone
• 4-Chlorobenzophenone
• PHENYL VALERATE
• Glycine
• Pigment Red 202
• 2-Cyclopropylmethylamino-5-chlorobenzophenone
• 2-Amino-2',5-dichlorobenzophenone
• Difluorochloromethane
• 2-Aminobenzylchloride
• 2-Amino-5-chloro-2'-fluorobenzophenone
• 2-Chloro-N-[4-chloro-2-(2-chlorobenzoyl)phenyl]acetamide
• 5-Chloro-2-(methylamino)benzophenone
• 2-AMINO-5-CHLOROBENZOPHENONE /CHLORDIAZEPOXIDE