ChemicalBook > Product Catalog > Chemical Reagents > Organic reagents > Polycyclic compound > TAK-931
TAK-931
TAK-931 Basic information
- Product Name:
- TAK-931
- Synonyms:
-
- 2-[(2S)-1-azabicyclo[2.2.2]octan-2-yl]-6-(5-methyl-1~{H}-pyrazol-4-yl)-3~{H}-thieno[3,2-d]pyrimidin-4-one
- SIMUROSERTIB
- TAK-931
- (S)-6-(3-methyl-1H-pyrazol-4-yl)-2-(quinuclidin-2-yl)thieno[3,2-d]pyrimidin-4(3H)-one
- Simurosertib (TAK-931)
- Thieno[3,2-d]pyrimidin-4(3H)-one, 2-(2S)-1-azabicyclo[2.2.2]oct-2-yl-6-(3-methyl-1H-pyrazol-4-yl)-
- TAK-931，Simurosertib
- Inhibitor,anti-cancer,Cyclin dependent kinase,ATP-competitive,CDK,TAK931,Simurosertib,cycle,cell,orally,inhibit,division,TAK 931
- CAS:
- 1330782-76-7
- MF:
- C17H19N5OS
- MW:
- 341.43
- Mol File:
- 1330782-76-7.mol
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TAK-931 Chemical Properties
- storage temp.
- Store at -20°C
- solubility
- DMSO: soluble
- form
- A solid
- color
- White to off-white
- InChI
- InChI=1S/C17H19N5OS/c1-9-11(8-18-21-9)14-7-12-15(24-14)17(23)20-16(19-12)13-6-10-2-4-22(13)5-3-10/h7-8,10,13H,2-6H2,1H3,(H,18,21)(H,19,20,23)/t13-/m0/s1
- InChIKey
- XGVXKJKTISMIOW-ZDUSSCGKSA-N
- SMILES
- C1([C@@H]2CC3CCN2CC3)NC(=O)C2SC(C3=CNN=C3C)=CC=2N=1
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TAK-931 Usage And Synthesis
Uses
Simurosertib (TAK-931) is an orally active, selective and ATP-competitive cell division cycle 7 (CDC7) kinase inhibitor, with an IC50 of <0.3 nM. Simurosertib has anti-cancer activity[1].
in vivo
In the COLO205-xenograft mouse model, oral administration of Simurosertib (TAK-931) inhibits pMCM2 of the xenografted COLO205 in dose- and time-dependent manners. Furthermore, Simurosertib (TAK-931) exhibits a significant antitumor activity in multiple xenograft models[1].
IC 50
Cdc7: <0.3 nM (IC50)
References
[1] K Iwai, et al. A novel CDC7-selective inhibitor TAK-931 with potent antitumor activity. European Journal of Cancer , 2016 , 69 (1) :S34.
TAK-931Supplier
Suzhou Chenrui Biotechnology Co. LTD Gold
- Tel
- 17625585511
- 1580084073@qq.com
ShangHai Caerulum Pharma Discovery Co., Ltd.
- Tel
- 18149758185
- sales-cpd@caerulumpharma.com
Shanghai YuanQi Biotechnology Co., Ltd.
- Tel
- +86-2332782371 +86-18120098618
- sales@adobechem.com
Shanghai Lollane Biological Technology Co.,Ltd.
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- 021-52996696，15000506266 15000506266
Shanghai EFE Biological Technology Co., Ltd.
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- 021-65675885 18964387627
- info@efebio.com