PF-9366 Chemical Properties

Melting point:

182-183.5 °C(Solv: ethyl acetate (141-78-6); hexane (110-54-3))

Density 

1.25±0.1 g/cm3(Predicted)

storage temp. 

2-8°C

solubility 

Soluble in DMSO (up to 20 mg/ml).

pka

8.75±0.28(Predicted)

form 

solid

color 

Beige

Stability:

Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.

PF-9366 Usage And Synthesis

Description

PF-9366 (72882-78-1) is an allosteric inhibitor (IC50?= 420 nM) of methionine adenosyltransferase 2A (Mat2A), the primary enzyme responsible for extrahepatic synthesis of S-adenosyl-L-methionine (SAM).1?It inhibited cellular SAM production in H520 lung and Huh-7 liver cancer cells with IC50’s of 1.2 μM and 225 nM respectively.

Uses

PF-9366 is a novel inhibitor of human methionine adenosyltransferase 2A (Mat2A), the extrahepatic isoform.

References

1) Quinlan?et al. (2017),?Targeting S-adenosylmethionine biosynthesis with a novel allosteric inhibitor of Mat2A; Nat. Chem. Biol.,?13?785

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