Sineptina Chemical Properties

Melting point:

128-145 °C

storage temp. 

Sealed in dry,2-8°C

solubility 

ethanol: 50 mg/mL, clear to slightly hazy, light-yellow

form 

Solid

color 

White to Off-White

Merck 

14,5453

CAS DataBase Reference

1392-21-8

Safety Information

Safety Statements 

24/25

WGK Germany 

1

RTECS 

WG9400000

F 

10

HS Code 

29419090

Toxicity

mouse,LD50,intraperitoneal,1758mg/kg (1758mg/kg),Drugs in Japan Vol. -, Pg. 354, 1995.

MSDS

• Language:English Provider:SigmaAldrich

Sineptina Usage And Synthesis

Description

Kitasamycin, formerly called leucomycin, was found in the culture broth of Streptoverticillium kitasatoensis by Hata et al. of the Kitasato Institute, Japan, in 1953. This was the first macrolide antibiotic with a 16-membered lactone constituent. Kitasamycin is a complex of eight leucomycin A components and is used in its base and ester forms to treat gram-positive bacterial and gram-negative coccal infections, as well as infections of Mycoplasma, Spirochaeta, and Treponema by injection or by oral topical administration.

Uses

Leucomycins (>85%) (cas# 1392-21-8) is a compound useful in organic synthesis.

Uses

Sineptina is a family of closely related macrocyclic lactone antibiotics produced by Streptomyces kitasatoensis, discovered in 1953. The complex contained over 14 components with analogues A1, A4, A5, and A13 being the most abundant analogues.Sineptina is used as an animal health product for control of Gram positive bacteria, Gram negative cocci, leptospira and mycoplasma.

Definition

ChEBI: Leucomycin V is a macrolide antibiotic produced by Streptomyces kitasatoensis, showing activity against a wide spectrum of pathogens. It has a role as a bacterial metabolite. It is a leucomycin and a macrolide antibiotic.

Pharmaceutical Applications

A naturally occurring product of Streptomyces kitasatoensis, available in Japan for parenteral and oral use, and as acetylkitasamycin for topical application. Elsewhere it is chiefly used in veterinary medicine.

Sineptina(1392-21-8)Related Product Information

• Hyodeoxycholic acid
• HYPOCRELLIN A
• oleandomycin
• TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)DYSPROSIUM(III)
• METHYL ISOCYANOACETATE
• SALCOMINE
• Tris(2,4-pentanedionato)chroMiuM(III)
• TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)EUROPIUM(III)
• Benzyl isocyanide
• Cupric acetylacetonate
• Aluminum acetylacetonate
• DICHLORO(ETHYLENEDIAMINE)PLATINUM(II)
• TERT-BUTYL ISOCYANIDE
• PHENYLSELENOL
• 2,4-PENTANEDIONE, SILVER DERIVATIVE
• Ethyl isocyanoacetate
• N-BUTYLISOCYANIDE
• COBALT(II) ACETYLACETONATE