4-BROMO-2,3-DIMETHYLANISOLE Chemical Properties

Boiling point:

197 °C (lit.)

Density 

1.36 g/mL at 25 °C (lit.)

refractive index 

n20/D 1.566(lit.)

Flash point:

>230 °F

storage temp. 

Sealed in dry,Room Temperature

Appearance

Colorless to light yellow Liquid

InChI

1S/C9H11BrO/c1-6-7(2)9(11-3)5-4-8(6)10/h4-5H,1-3H3

InChIKey

WOWNZZYJCUUIFC-UHFFFAOYSA-N

SMILES

COc1ccc(Br)c(C)c1C

CAS DataBase Reference

50638-48-7

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

WGK Germany 

3

HazardClass 

IRRITANT

Storage Class

10 - Combustible liquids

Hazard Classifications

Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

MSDS

• Language:English Provider:SigmaAldrich

4-BROMO-2,3-DIMETHYLANISOLE Usage And Synthesis

Uses

4-Bromo-2,3-dimethylanisole may be used in the preparation of:

• 4,6-Dibromo-2,3-dimethylanisole via bromination using NBS-CH₃CN system.
• 4-Methoxy-2,2′,3,3′-tetramethyldiphenyl ether by reacting with 2,3-dimethylphenol.
• A novel arylsulfonamide derivative with potent glucocorticoid receptor (GR) agonist activity.

General Description

4-Bromo-2,3-dimethylanisole can be prepared from 2,3-dimethylanisole via bromination using N-bromosuccinimide-acetonitrile (NBS-CH₃CN) system.

Synthesis

4-Bromo-2,3-dimethylanisole is generally obtained by the bromination of 2,3-dimethylanisole, the bromination reagent being either bromine or NBS.

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