1,4-Cineole Chemical Properties

Melting point:

-46 °C (lit.)

Boiling point:

65 °C/16 mmHg (lit.)

Density 

0.887 g/mL at 25 °C (lit.)

refractive index 

n20/D 1.445(lit.)

FEMA 

3658 | 1,4-CINEOLE

Flash point:

118 °F

storage temp. 

Store at -20°C

Water Solubility 

Slightly soluble in water

solubility 

Almost insoluble in water, soluble in alcohol and oils. DMSO: 125 mg/mL (810.37 mM)

form 

Liquid

color 

Colorless to Almost colorless

Odor

Cool, somewhat spicy-herbaceous taste

Odor Type

herbal

JECFA Number

1233

BRN 

104974

LogP

2.97

CAS DataBase Reference

470-67-7(CAS DataBase Reference)

NIST Chemistry Reference

7-Oxabicyclo[2.2.1]heptane, 1-methyl-4-(1-methylethyl)-(470-67-7)

EPA Substance Registry System

1,4-Cineole (470-67-7)

Safety Information

Risk Statements 

10

Safety Statements 

16

RIDADR 

UN 1993 3/PG 3

WGK Germany 

2

RTECS 

OS9274000

F 

10

HS Code 

2932.19.5100

HazardClass 

3.2

PackingGroup 

III

Hazardous Substances Data

470-67-7(Hazardous Substances Data)

MSDS

• Language:English Provider:SigmaAldrich

1,4-Cineole Usage And Synthesis

Chemical Properties

1,4-Cineole has a light and mild camphoraceous odor and a cool, mildly spice-like flavor.

Occurrence

Reported present in Piper cubeba, lime peel oil, apricot, cardamom (Eleteria cardamomun Maton), orange juice, grapefruit juice, laurel (Laurus nobilis L), rosemary and mastic gum leaf oil. It is also present in various essential oils; Boldea fragrans Juss., Xanthoxylum rhetsa D.C. and Ormenis multicaulis.

Uses

Apart from the academic interest related to the olfactory similarity or dissimilarity) of isomer chemicals, there is not much interest in this chemical. It is not nearly as readily available as its isomer, Eucalyptol.

Definition

ChEBI: 1,4-cineole is an oxabicycloalkane consisting of p-menthane with an epoxy bridge across positions 1 and 4. It has a role as a plant metabolite, a fumigant insecticide and a central nervous system depressant. It is a cineole and an oxabicycloalkane.

Taste threshold values

Taste characteristics at 40 ppm: cooling, minty, menthol-like, green and herbal, with a terpy and camphoraceous nuance.

General Description

1,4-Cineole is present in eucalyptus oil. It activated both human TRPA1 (a sensor of noxious cold) and human TRPM 8 (a thermosensitive receptor). It is a natural monoterpene that inhibits plant growth.

Synthesis

Its structure has been confirmed through synthesis.*

1,4-Cineole(470-67-7)Related Product Information

• Heptane
• Isopropyl alcohol
• Methylparaben
• Methyl acrylate
• Bensulfuron methyl
• 1,8-Cineole
• ISOPROPYL LAURATE
• Kresoxim-methyl
• Methyl
• Parathion-methyl
• Methyl bromide
• Cinmethylin
• 2,2,5,5-TETRAMETHYLTETRAHYDROFURAN
• 7-OXABICYCLO[2.2.1]HEPTANE
• 1,4-Cineole
• Eucalyptol Ex-Eucalyptus Oil
• (-)-end-2-Hydroxy-1,8-cineole,2α-Hydroxy-1,8-cineole
• 2,3-dehydro-1,8-cineole,1,3,3-trimethyl-2-oxabicyclo[2.2.2]oct-5-ene,dehydrocineole