4-Amino-2,6-difluorophenol Chemical Properties

Melting point:

0°C

Boiling point:

0°C

Density 

1.472±0.06 g/cm3(Predicted)

Flash point:

0°C

storage temp. 

Sealed in dry,Room Temperature

pka

7.72±0.23(Predicted)

form 

solid

color 

Brown

CAS DataBase Reference

126058-97-7

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

HS Code 

2908990000

4-Amino-2,6-difluorophenol Usage And Synthesis

Synthesis

General procedure for the synthesis of 4-amino-2,6-difluorophenol from 2-(benzyloxy)-1,3-difluoro-5-nitrobenzene: To a solution of 2-(benzyloxy)-1,3-difluoro-5-nitrobenzene (5.3 g, 20 mmol) in ethanol (100 mL) was added 10% palladium/activated carbon (1.5 g). The reaction mixture was stirred overnight at room temperature and 1 atmosphere of hydrogen at 1 atm. Upon completion of the reaction, the catalyst was removed by filtration and the filtrate was concentrated under reduced pressure to afford 4-amino-2,6-difluorophenol (2.9 g, 95% yield). The structure of the product was confirmed by 1H NMR (400 MHz, DMSO-d6): δ 8.68 (br s, 1H), 6.19 (d, J = 10.8 Hz, 2H), 5.01 (s, 2H).

References

[1] Patent: WO2010/51373, 2010, A1. Location in patent: Page/Page column 68

4-Amino-2,6-difluorophenol(126058-97-7)Related Product Information

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