ChemicalBook > Product Catalog > API > Hormones and the Endocrine System > Estrogen and progestin drugs > Nomegestrol 17-acetate
Nomegestrol 17-acetate
Nomegestrol 17-acetate Basic information
- Product Name:
- Nomegestrol 17-acetate
- Synonyms:
-
- 19-Norpregna-4,6-diene-3,20-dione,17-(acetyloxy)-6-Methyl-
- 17-Acetoxy-6-methyl-19-norpregna-4,6-diene-3,20-dione
- Org 10486-0
- Nomegestrol Acetate-d3
- MELEGESTROL ACETATE
- 17-hydroxy-6-methyl-19-norpregna-4,6-diene-3,20-dione 17-acetate
- 17ALPHA-ACETOXY-6ALPHA-METHYL-19-NOR-PREGN-4,6-DIEN-3,20-DIONE
- nomegestrol 17-acetate
- CAS:
- 58652-20-3
- MF:
- C23H30O4
- MW:
- 370.48
- EINECS:
- 261-379-8
- Product Categories:
-
- Intermediates & Fine Chemicals
- Pharmaceuticals
- Steroids
- Mol File:
- 58652-20-3.mol
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Nomegestrol 17-acetate Chemical Properties
- Boiling point:
- 507.3±50.0 °C(Predicted)
- Density
- 1.16±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO: ≥7mg/mL
- form
- powder
- color
- white to tan
- InChIKey
- IIVBFTNIGYRNQY-YQLZSBIMSA-N
- SMILES
- C1(=O)C=C2[C@]([H])(CC1)[C@]1([H])[C@]([H])([C@@]3([H])[C@@](CC1)(C)[C@@](OC(C)=O)(C(=O)C)CC3)C=C2C
- CAS DataBase Reference
- 58652-20-3(CAS DataBase Reference)
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Nomegestrol 17-acetate Usage And Synthesis
Chemical Properties
White or almost white, crystalline powder.
Uses
Nomegestrol 17-acetate is a progetin used in implantable hormone replacement therapies.
Uses
Contraceptive
Definition
ChEBI: Nomegestrol acetate is a corticosteroid hormone.
in vivo
Nomegestrol acetate (50, 100, 200 mg/kg; p.o.; single daily for 28 days) inhibits growth of RL95-2 xenograft tumors in vivo[1].
Nomegestrol acetate (100, 200 mg/kg; p.o.; single daily for 28 days) surpresses the expression of SUFU and Wnt7a in tumor tissues[1].
Nomegestrol acetate (1, 2.5 mg/rat; p.o.; single daily for 4 days) inhibits ovulation in rats[2].
| Animal Model: | Female athymic nude mice (BALB/c; 18-20 g; 6 to 7-week-old; xenograft nude mouse model)[1]. |
| Dosage: | 50, 100, 200 mg/kg |
| Administration: | Oral gavage; single daily for 28 days |
| Result: | Reduced the growth of RL95-2 xenograft tumors in vivo. Upregulated the expression of SUFU and Wnt7a in a dose-dependent manner when at 100 and 200 mg/kg. |
| Animal Model: | Mature female Wistar rats (~200 g)[2]. |
| Dosage: | 1, 2.5 mg/rat |
| Administration: | Oral administration; single daily for 4 days |
| Result: | Showed only one animal ovulated after receiving 1 mg/kg per day, and no animals ovulated after receiving 2.5 mg/rat per day. |
Nomegestrol 17-acetateSupplier
Yunfei Pharmaceutical(Shenzhen) Co., Ltd. Gold
- Tel
- 0755-61160828 15994832653
- hulixiu@yunfeipharma.com
Hunan Jiuwei Biopharmaceutical Co., Ltd Gold
- Tel
- 19176660800; 19176660800
- alexybw@hnjwpharma.com
Changsha Qisheng Heyan Medical Technology Co., LTD Gold
- Tel
- 18684929597
- 527907673@qq.com
Chemvon Biotechnology Co., Ltd
- Tel
- 021-50790412
- info@chemvon.com
ZHIWE CHEMTECH CO LTD
- Tel
- 021-20221225 13917446399
- zwchem@163.com