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Methyl 3-amino-2-pyrazinecarboxylate

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Methyl 3-amino-2-pyrazinecarboxylate Basic information

Product Name:
Methyl 3-amino-2-pyrazinecarboxylate
Synonyms:
  • METHYL 2-AMINOPYRAZINE-3-CARBOXYLATE
  • METHYL 3-AMINO-2-PYRAZINECARBOXYLATE
  • METHYL 3-AMINOPYRAZINE-2-CARBOXYLATE
  • BUTTPARK 35\02-15
  • 3-AMINOPYRAZINE-2-CARBOXYLIC ACID METHYL ESTER
  • AKOS 90402
  • TIMTEC-BB SBB004048
  • methyl 3-aminopyrazinecarboxylate
CAS:
16298-03-6
MF:
C6H7N3O2
MW:
153.14
EINECS:
240-387-5
Product Categories:
  • amine| carboxylic ester
  • Amines
  • Pyrazinecarboxylic Acid & Derivatives
  • Heterocycles
  • Building Blocks
  • Heterocyclic Building Blocks
  • Pyrazines
  • Heterocyclic Compounds
  • Chemical Amines
  • Pyrazine
Mol File:
16298-03-6.mol
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Methyl 3-amino-2-pyrazinecarboxylate Chemical Properties

Melting point:
169-172 °C (lit.)
Boiling point:
300.8±37.0 °C(Predicted)
Density 
1.319±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,2-8°C
solubility 
Chloroform, Methanol
pka
-0.30±0.10(Predicted)
form 
Crystalline Powder
color 
Yellow
BRN 
127495
InChIKey
INCSQLZZXBPATR-UHFFFAOYSA-N
LogP
0.2 at 20℃ and pH7
Surface tension
73.3mN/m at 1g/L and 20℃
CAS DataBase Reference
16298-03-6(CAS DataBase Reference)
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Safety Information

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
22-24/25-37/39-26
WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
29339900

MSDS

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Methyl 3-amino-2-pyrazinecarboxylate Usage And Synthesis

Chemical Properties

yellow crystalline powder

Uses

Methyl 3-amino-2-pyrazinecarboxylate has been used in:

  • synthesis of 2-arylpteridin-4-ones and piperazine-derived 2-furan-2-yl-[1,2,4]triazolo[1,5-a] pyrazines
  • reactions with isocyanates and aroyl chlorides for conversion to pteridinediones

Definition

ChEBI: Methyl 3-aminopyrazine-2-carboxylate is a pyrazine that is substituted by a methoxycarbonyl group at position 2 and an amino group at position 3. It is a member of pyrazines, a methyl ester and an aromatic amine.

Purification Methods

The ester forms yellow needles from H2O (100 parts using charcoal). If it contains the free acid (see IR), then dissolve it in CH2Cl2, wash it with saturated aqueous Na2CO3, brine, dry over MgSO4 filter, evaporate and recrystallise the residue. The free acid has m 203-204o (dec) [UV: Brown & Mason J Chem Soc 3443 1956] and pK1 <1 and pK2 3.70. The ammonium salt has m 232o(dec) (from aqueous Me2CO) and the amide has m 239.2o (from H2O) [Ellingson et al. J Am Chem Soc 67 1711 1945]. [Beilstein 25 III/IV 4412.]

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