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H-DAB(BOC)-OH

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H-DAB(BOC)-OH Basic information

Product Name:
H-DAB(BOC)-OH
Synonyms:
  • H-DAB(BOC)-OH
  • ALPHA,GAMMA-DIAMINOBUTYRIC ACID(BOC)-OH
  • N-GAMMA-T-BUTOXYCARBONYL-L-ALPHA,GAMMA-DIAMINOBUTYRIC ACID
  • N-GAMMA-BOC-L-2,4-DIAMINOBUTYRIC ACID
  • (2S)-Amino-4-[(tert-butoxycarbonyl)amino]butanoic acid
  • (2S)-2-amino-4-{[(tert-butoxy)carbonyl]amino}butanoic acid
  • L-Dab(Boc)-OH
  • H-Daba(Boc)-OH
CAS:
10270-94-7
MF:
C9H18N2O4
MW:
218.25
Mol File:
10270-94-7.mol
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H-DAB(BOC)-OH Chemical Properties

Melting point:
216℃
Boiling point:
388.2±37.0 °C(Predicted)
Density 
1.160±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,2-8°C
form 
Solid
pka
2.25±0.10(Predicted)
color 
White to off-white
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H-DAB(BOC)-OH Usage And Synthesis

Chemical Properties

White crystalline powder

Uses

H-Dab(Boc)-OH is an amino acid derivative with a Boc protecting group, which can be used to synthesize methotrexate (MTX) analogs with antitumor and antifolate activities[1].

References

[1] Rosowsky, et al. "Methotrexate analogs. 26. Inhibition of dihydrofolate reductase and folylpolyglutamate synthetase activity and in vitro tumor cell growth by methotrexate and aminopterin analogs containing a basic amino acid side chain." Journal of medicinal chemistry 29.5 (1986): 655-660. DOI:10.1021/jm00155a012

H-DAB(BOC)-OHSupplier

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