(3N-[(2S,3S)-2-AMINO-3-METHYL-PENTANOYL]-1,3-THIAZOLIDINE) HEMIFUMARATE
(3N-[(2S,3S)-2-AMINO-3-METHYL-PENTANOYL]-1,3-THIAZOLIDINE) HEMIFUMARATE Basic information
- Product Name:
- (3N-[(2S,3S)-2-AMINO-3-METHYL-PENTANOYL]-1,3-THIAZOLIDINE) HEMIFUMARATE
- Synonyms:
-
- (3N-[(2S,3S)-2-AMINO-3-METHYL-PENTANOYL]-1,3-THIAZOLIDINE) HEMIFUMARATE
- P32/98
- 1-Pentanone, 2-amino-3-methyl-1-(3-thiazolidinyl)-, (2S,3S)-
- P32/98, dipeptidyl peptidase IV (DPP4) inhibitor
- CAS:
- 136259-20-6
- MF:
- C9H18N2OS
- MW:
- 202.32
- Mol File:
- 136259-20-6.mol
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(3N-[(2S,3S)-2-AMINO-3-METHYL-PENTANOYL]-1,3-THIAZOLIDINE) HEMIFUMARATE Chemical Properties
- Boiling point:
- 351.8±37.0 °C(Predicted)
- Density
- 1.118±0.06 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- Soluble in DMSO (up to 25 mg/ml) or in Water (up to 20 mg/ml).
- form
- White solid.
- pka
- 8.53±0.39(Predicted)
- color
- White
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 1 month.
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(3N-[(2S,3S)-2-AMINO-3-METHYL-PENTANOYL]-1,3-THIAZOLIDINE) HEMIFUMARATE Usage And Synthesis
Description
P32/98 (136259-20-6) is a potent and selective inhibitor of dipeptidyl peptidase IV (DPPIV) (Ki=130 nM). May be used in cell cuture (1-10 μM) or in vivo (10 mg/kg orally). Cell permeable. Experimental anti-diabetic agent. This product not approved for human therapeutic use.
Uses
P32/98 is a dipeptidyl peptidase IV inhibitor which is used in hypertensive patients treated with antihpertensive drugs.
in vivo
P32/98 (25 mg/kg; i.g.; once daily) long-time treatment significantly improves the glucose tolerance in Zucker diabetic fatty rats, a model of IGT (impaired glucose tolerance)[3].
| Animal Model: | Zucker diabetic fatty rat[2] |
| Dosage: | 25 mg/kg |
| Administration: | Oral gavage; once daily |
| Result: | Significantly improved the glucose tolerance in Zucker diabetic fatty rats. |
(3N-[(2S,3S)-2-AMINO-3-METHYL-PENTANOYL]-1,3-THIAZOLIDINE) HEMIFUMARATESupplier
Credit Asia Chemical Co., Ltd.
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- +86 (21) 61124340
Shanghai EFE Biological Technology Co., Ltd.
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- 021-65675885 18964387627
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StressMarq Biosciences Inc
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- 1250-294-9065
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Enzo Biochem Inc
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- Enzo Biochem Inc. 13797054060
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Santa Cruz Biotechnology Inc
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- 021-60936350
- scbt@scbt.com