1-Chloroisoquinoline Chemical Properties

Melting point:

31-36 °C (lit.)

Boiling point:

274-275 °C/768 mmHg (lit.)

Density 

1.2108 (rough estimate)

refractive index 

1.6342 (estimate)

Flash point:

>230 °F

storage temp. 

Inert atmosphere,2-8°C

form 

Low Melting Solid, Crystals and/or Chunks

pka

2.03±0.30(Predicted)

color 

White to yellow

Water Solubility 

Insoluble in water.

BRN 

2996

InChIKey

MSQCQINLJMEVNJ-UHFFFAOYSA-N

CAS DataBase Reference

19493-44-8(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

WGK Germany 

3

HS Code 

29334900

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

1-Chloroisoquinoline Usage And Synthesis

Chemical Properties

white to yellow low melting solid, crystals and/or

Uses

Used in a Mn-catalyzed cross-coupling with aryl- and alkylmagnesium halides.1 Also used in a Pd-catalyzed cross-coupling with heteroaryl boronic acids and esters.2

Uses

1-Chloroisoquinone is used in the preparation of new aminoisoquinolinylurea derivatives which show antiproliferative activity against melanoma cell lines. It can also be applied to the control of stor age and stability of unstable boronic acids.

Uses

The product has been used in a Mn-catalyzed cross-coupling with aryl- and alkylmagnesium halides. It has also been used in a Pd-catalyzed cross-coupling with heteroaryl boronic acids and esters. Furthermore, it has been used in a homocoupling reaction to yield bis-isoquinoline, each enantiomer of which might be very useful as a chiral ligand for asymmetric synthesis. 1-Chloroisoquinone is used in the preparation of new aminoisoquinolinylurea derivatives which show antiproliferative activity against melanoma cell lines. It can also be applied to the control of storage age and stability of unstable boronic acids.

1-Chloroisoquinoline(19493-44-8)Related Product Information

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