4-Chloroquinoline Chemical Properties

Melting point:

28-31 °C (lit.)

Boiling point:

260-261 °C (lit.)

Density 

1.25 g/mL at 20 °C (lit.)

refractive index 

1.6110 (estimate)

Flash point:

>230 °F

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

form 

powder to lump

pka

3.57±0.13(Predicted)

color 

White to Almost white

Water Solubility 

Partly soluble in water.

λmax

316nm(EtOH aq.)(lit.)

BRN 

114721

InChIKey

KNDOFJFSHZCKGT-UHFFFAOYSA-N

CAS DataBase Reference

611-35-8(CAS DataBase Reference)

NIST Chemistry Reference

4-Chloroquinoline(611-35-8)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-37/39-36

WGK Germany 

3

Hazard Note 

Irritant

HS Code 

29339900

MSDS

• Language:English Provider:SigmaAldrich

4-Chloroquinoline Usage And Synthesis

Chemical Properties

Pale yellow low melting solid

Uses

4-Chloroquinoline is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuffs.

Purification Methods

Possible impurities include the 2-isomer. It is best purified by converting to the picrate (m 212-213o dec) in EtOH and recrystallising it from EtOH (where the picrate of the 2-chloroquinoline remains in solution) or EtOAc . The picrate is decomposed with 5% aqueous NaOH, extracted in CHCl3, washed with H2O, dried (MgSO4), evaporated and distilled in a vacuum. It can be steam distilled from slightly alkaline aqueous solutions, the aqueous distillate is extracted with Et2O, evaporated and distilled. The distillate solidifies on cooling. [Bobránski Chem Ber 71 578 1938, Beilstein 20/7 V 314.]

4-Chloroquinoline(611-35-8)Related Product Information

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