2,6-Dichloropyridine Chemical Properties

Melting point:

83-86 °C (lit.)

Boiling point:

211 °C

Density 

1.5159 (rough estimate)

refractive index 

1.5500 (estimate)

Flash point:

110°C

storage temp. 

Inert atmosphere,2-8°C

solubility 

methanol: 50 mg/mL, clear

form 

Crystalline Powder

pka

-3.02±0.10(Predicted)

color 

White to pink or grayish-white

PH

6-7 (H2O, 20℃)(saturated solution)

Water Solubility 

<1 g/L (20 ºC)

BRN 

108664

InChIKey

FILKGCRCWDMBKA-UHFFFAOYSA-N

CAS DataBase Reference

2402-78-0(CAS DataBase Reference)

NIST Chemistry Reference

Pyridine, 2,6-dichloro-(2402-78-0)

EPA Substance Registry System

2,6-Dichloropyridine (2402-78-0)

Safety Information

Hazard Codes 

T,Xn

Risk Statements 

25-36/37/38-22-23/24/25

Safety Statements 

36/37/39-45-37/39-26-36

RIDADR 

UN 2811 6.1/PG 2

WGK Germany 

3

RTECS 

US8400000

Hazard Note 

Toxic

TSCA 

Yes

HazardClass 

6.1

PackingGroup 

III

HS Code 

29333999

Toxicity

mouse,LD50,intraperitoneal,115mg/kg (115mg/kg),BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)LIVER: FATTY LIVER DEGERATIONBEHAVIORAL: ANTIPSYCHOTIC,Toxicology and Applied Pharmacology. Vol. 11, Pg. 361, 1967.

MSDS

• Language:English Provider:2,6-Dichloropyridine
• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

2,6-Dichloropyridine Usage And Synthesis

Synthesis

2-chloropyridine or 2-chloropyridine hydrochloride reacting with chlorine under photoinitiation actions at 160-190 ℃ to generate the 2,6-dichloropyridine.

Description

2,6-Dichloropyridine is an important intermediate that is widely used in the medicine and pesticide research field. It could be used as a starting material to synthesize the pirozadil (Pirozadil) which can be used for reducing blood-fat, and antiplatelet condensation. 2,6-dichloropyridine also can be used to synthetic musk pyridine with alternative natural musk. 2,3,5, 6-TCP produced by further chlorination of 2, 6-dichloropyridine is an important raw material for chlorpyrifos, which is widely used in the world with high efficiency, broad spectrum, and low residue.

Chemical Properties

White to light yellow solid

Uses

2,6-Dichloropyridine is used in the preparation of triazolo and imidazo potassium channel antagonists as antiarrythmic agents.

Purification Methods

It crystallises from EtOH. [Beilstein 20/5 V 416.]

2,6-Dichloropyridine(2402-78-0)Related Product Information

• Dichloroethane
• 2,6-Lutidine
• 2-Chloro-5-chloromethylpyridine
• 2,2'-Bipyridine
• Thionyl chloride
• 2,5-Dichloropyridine
• 2-Bromo-5-nitropyridine
• 1,2-Dichloroethane
• 2-Chloro-3-hydroxypyridine
• 2-[3-[Bis(2-chloroethyl)aMino]propyl]-1,2,4-triazolo[4,3-a]pyridin-3(2H)-one
• 1,2,4-Triazolo[4,3-a]pyridin-3(2H)-one, 2-[3-[4-(3-chlorophenyl)-1-piperazinyl]propyl]-7,8-dihydro-7,8-dihydroxy-
• Trazodone-D6 Hydrochloride
• Isotrazodone
• Piperazine, 1-(3-broMopropyl)-4-(3-chlorophenyl)-
• Trazodone Hydrochloride BP Impurity H DiHCl
• Trazodone
• Trazodone Impurity 28
• 4-chloropyridine