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L-Histidine hydrochloride monohydrate

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L-Histidine hydrochloride monohydrate Basic information

Product Name:
L-Histidine hydrochloride monohydrate
Synonyms:
  • L-ALPHA-AMINO-4(OR 5)-IMIDAZOLEPROPIONIC ACID MONOHYDROCHLORIDE, MONOHYDRATE
  • L-ALPHA-AMINO-BETA-(4-IMIDAZOLYL)PROPIONIC ACID MONOHYDROCHLORIDE
  • L-HIS HCL H2O
  • L-HISTIDINE MONOHYDROCHLORIDE H2O
  • L-(+)-HISTIDINE HYDROCHLORIDE MONOHYDRATE
  • L-HISTIDINE HYDROCHLORIDE MONOHYDRATE
  • L-HISTIDINE MONOHYDROCHLORIDE MONOHYDRATE
  • L-HISTIDINE HCL H2O
CAS:
5934-29-2
MF:
C6H12ClN3O3
MW:
209.63
EINECS:
611-821-4
Product Categories:
  • Amino Acid Derivatives
  • alpha-Amino Acids
  • Amino Acids
  • Biochemistry
  • L-Amino Acids
Mol File:
5934-29-2.mol
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L-Histidine hydrochloride monohydrate Chemical Properties

Melting point:
254 °C (dec.)(lit.)
alpha 
9.9 º (c=11, 6 N HCl)
Density 
1.49 g/cm3
vapor pressure 
<1 hPa (20 °C)
storage temp. 
Store below +30°C.
solubility 
H2O: 100 mg/mL
form 
Solid
color 
White
PH
3.5-4.5 (100g/l, H2O, 20℃)
PH Range
3 - 4 at 105 g/l at 25 °C
optical activity
[α]20/D +9.5±0.5°, c = 5% in 5 M HCl
Water Solubility 
169.9 g/L (20 ºC)
Merck 
14,4720
BRN 
4168261
InChIKey
CMXXUDSWGMGYLZ-XRIGFGBMSA-N
CAS DataBase Reference
5934-29-2(CAS DataBase Reference)
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Safety Information

Hazard Codes 
Xn
Risk Statements 
22-36/37/38
Safety Statements 
22-24/25-36/37-26
WGK Germany 
3
RTECS 
MS3119000
10
TSCA 
Yes
HS Code 
29332990

MSDS

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L-Histidine hydrochloride monohydrate Usage And Synthesis

Chemical Properties

white crystals or cryst. or granular powder

Uses

L-Histidine is used in cell culture media formulations used in biomanufacturing. L-Histidine has been used to study cultures of the human T-lymphoblastic leukemia cell line MOLT-4 to study modulation of apoptosis.

General Description

Chemicals play an important role in the stabilization of a biologic drug during its manufacturing and formulation process – for instance, by preventing aggregation. We offer a wide range of high-quality stabilizers, buffers and salts to successfully purify and formulate your biomolecules. Specifically developed for high-risk applications, they are low in bioburden and endotoxins.
As part of our Emprove? Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC? portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Biochem/physiol Actions

L-Histidine is biosynthesized from ATP, 5-phosphoribosyl-1-pyrophosphate (PRPP), and glutamine. This essential amino acid can be degraded to glutamate by histidiase, urocanase and imidazolonepropionase; it is also the precursor of histamine by action of histidine decarboxylase.

Purification Methods

Crystallise the monohydrochloride from aqueous EtOH or 60% aqueous EtOH (m 259odec). Alternatively dissolve 10g in 50mL of H2O, decolourise with Norite, filter, evaporate it in a vacuum to a syrup, cool to room temperature, add 95% EtOH with stirring until slightly turbid, scratch the sides of the vessel until crystals form, then add slowly 40mL of EtOH and keep at 0o overnight, filter the solid off, wash it several times with EtOH and dry it in a vacuum. [Cox J Biol Chem 78 475 1929, Cox et al. J Biol Chem 81 73 1929, Greenstein & Winitz The Chemistry of the Amino Acids J. Wiley, Vol 3 pp 1972, 2098 1961, Beilstein 25 II 407, 25 III/IV 4346.]

L-Histidine hydrochloride monohydrate Preparation Products And Raw materials

Raw materials

L-Histidine hydrochloride monohydrateSupplier

Nantong puyue biomedical Co., Ltd Gold
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J & K SCIENTIFIC LTD.
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Meryer (Shanghai) Chemical Technology Co., Ltd.
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INTATRADE GmbH
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+49 3493/605464
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3B Pharmachem (Wuhan) International Co.,Ltd.
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821-50328103-801
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