L-Histidine hydrochloride monohydrate Chemical Properties

Melting point:

254 °C (dec.)(lit.)

alpha 

9.9 º (c=11, 6 N HCl)

Density 

1.49 g/cm3

vapor pressure 

<1 hPa (20 °C)

storage temp. 

Store below +30°C.

solubility 

H₂O: 100 mg/mL

form 

Solid

color 

White

Odor

odorless

PH

3.5-4.5 (100g/l, H2O, 20℃)

PH Range

3 - 4 at 105 g/l at 25 °C

optical activity

[α]20/D +9.5±0.5°, c = 5% in 5 M HCl

Water Solubility 

169.9 g/L (20 ºC)

Merck 

14,4720

BRN 

4168261

InChIKey

CMXXUDSWGMGYLZ-XRIGFGBMSA-N

LogP

-3.32 at 25℃

CAS DataBase Reference

5934-29-2(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xn

Risk Statements 

22-36/37/38

Safety Statements 

22-24/25-36/37-26

WGK Germany 

3

RTECS 

MS3119000

F 

10

TSCA 

Yes

HS Code 

29332990

MSDS

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L-Histidine hydrochloride monohydrate Usage And Synthesis

Chemical Properties

white crystals or cryst. or granular powder

Uses

L-Histidine is used in cell culture media formulations used in biomanufacturing. L-Histidine has been used to study cultures of the human T-lymphoblastic leukemia cell line MOLT-4 to study modulation of apoptosis.

Uses

L-Histidine monohydrochloride, non-animal, is used in cell culture media formulations used in biomanufacturing. The use of non-animal-sourced L-Histidine and other components avoids the risk of contaminating bioproducts with adventitious viruses.

Uses

L-Histidine Hydrochloride Monohydrate can be used as AhR activators to treat gluten-induced gastrointestinal diseases. It can also be used for hair coloring method.

General Description

Chemicals play an important role in the stabilization of a biologic drug during its manufacturing and formulation process – for instance, by preventing aggregation. We offer a wide range of high-quality stabilizers, buffers and salts to successfully purify and formulate your biomolecules. Specifically developed for high-risk applications, they are low in bioburden and endotoxins.
As part of our Emprove^? Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC^? portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Biochem/physiol Actions

L-Histidine is biosynthesized from ATP, 5-phosphoribosyl-1-pyrophosphate (PRPP), and glutamine. This essential amino acid can be degraded to glutamate by histidiase, urocanase and imidazolonepropionase; it is also the precursor of histamine by action of histidine decarboxylase.

Purification Methods

Crystallise the monohydrochloride from aqueous EtOH or 60% aqueous EtOH (m 259odec). Alternatively dissolve 10g in 50mL of H2O, decolourise with Norite, filter, evaporate it in a vacuum to a syrup, cool to room temperature, add 95% EtOH with stirring until slightly turbid, scratch the sides of the vessel until crystals form, then add slowly 40mL of EtOH and keep at 0o overnight, filter the solid off, wash it several times with EtOH and dry it in a vacuum. [Cox J Biol Chem 78 475 1929, Cox et al. J Biol Chem 81 73 1929, Greenstein & Winitz The Chemistry of the Amino Acids J. Wiley, Vol 3 pp 1972, 2098 1961, Beilstein 25 II 407, 25 III/IV 4346.]

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