1-Methylindole Chemical Properties

Melting point:

61.2°C (estimate)

Boiling point:

133 °C26 mm Hg(lit.)

Density 

1.051 g/mL at 20 °C(lit.)

refractive index 

n20/D 1.606(lit.)

Flash point:

>230 °F

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

solubility 

Chloroform (Soluble), DMSO (Slightly)

form 

Liquid, May Develop Some Turbidity or Precipitate

color 

Colorless to white

Water Solubility 

insoluble

Sensitive 

Light Sensitive

BRN 

111026

Stability:

Light sensitive. Combustible. Incompatible with strong oxidizing agents.

InChIKey

BLRHMMGNCXNXJL-UHFFFAOYSA-N

LogP

2.720

CAS DataBase Reference

603-76-9(CAS DataBase Reference)

NIST Chemistry Reference

1H-Indole, 1-methyl-(603-76-9)

EPA Substance Registry System

1H-Indole, 1-methyl- (603-76-9)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

22-24/25-37/39-26

RIDADR 

UN 3334

WGK Germany 

3

F 

13

TSCA 

Yes

HS Code 

29339990

MSDS

• Language:English Provider:1-Methylindole
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

1-Methylindole Usage And Synthesis

Chemical Properties

deep yellow viscous liquid with a very unpleasant smell

Uses

1-Methylindole is useful for the determination of association constant for the electron-donor-acceptor complexes with 1-(2,4,6-trinitrophenyl) propan-2-one. It acts as a reactant for the preparation of polycyclic derivatives of indoles, bisindole derivatives and pharmaceutically active 2-oxo-1-pyrrolidine analogues. It is also used as a reactant for the preparation of Positron Emission Tomography (PET) imaging agents of protein kinase C (PKC) and glycogen synthase kinase-3 (GSK-3).

Synthesis Reference(s)

Synthetic Communications, 26, p. 1349, 1996 DOI: 10.1080/00397919608003495
Tetrahedron Letters, 27, p. 377, 1986 DOI: 10.1016/S0040-4039(00)84023-X

General Description

1-Methylindole undergoes Au(III)/TPPMS-catalyzed benzylation reaction with benzhydryl and benzylic alcohols.

1-Methylindole(603-76-9)Related Product Information

• 1-METHYL-2-INDOLINONE
• 3-(1-methyl-1H-indole-3-carbonyl)hexanedioic acid
• (3R)-2,3-Dihydro-3-(2-propyn-1-ylaMino)-1H-inden-1-one
• 1-Methyl-1H-indole-3-carboxylic acid
• Ramosetron hydrochloride
• Rasagiline Impurity 5 Mesylate
• 5-(1-methyl-1H-indole-3-carbonyl)-1H-benzo[d]imidazol-2(3H)-one
• ramosetron
• 4,5,6,7-Tetrahydro-1H-benzoiMidazole-5-carboxylic acid hydrochloride
• Rasagiline Impurity 3
• 3a,7a-dihydroxy-5-(1-methyl-1H-indole-3-carbonyl)-hexahydro-1H-benzo[d]imidazol-2(3H)-one
• Ramosetron Impurity 13
• N-[4,5,6,7-Tetrahydrobenzimidazole-5-yl)carbonyl] pyrrolidine sulfate
• N-METHYLISATIN
• 2-Methylindole
• N-Ethylcarbazole
• 1-Methylindole-2-carboxylic acid
• 5-HYDROXY-2-METHYLINDOLE