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2-Ketoglutaric acid

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2-Ketoglutaric acid Basic information

Product Name:
2-Ketoglutaric acid
Synonyms:
  • 2-KETOGLUTARIC ACID
  • 2-OXOGLUTARIC ACID
  • 2-OXOPENTANEDIOIC ACID
  • A-KETOGLUTARIC ACID
  • Glutaric acid, 2-oxo-
  • Glutaric acid, alpha keto
  • -Ketoglutaricacid
  • α-Ketoglutaricacid
CAS:
328-50-7
MF:
C5H6O5
MW:
146.1
EINECS:
206-330-3
Product Categories:
  • Nutrition
  • food additives
  • Pharmaceutical Intermediates
  • Aliphatics
  • Organic acids
  • pharm raw material
  • Amino Acids
  • Food Additives
  • bc0001
  • 328-50-7
Mol File:
328-50-7.mol
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2-Ketoglutaric acid Chemical Properties

Melting point:
113-115 °C
Boiling point:
185.67°C (rough estimate)
Density 
1.2821 (rough estimate)
vapor pressure 
0.01Pa at 25℃
refractive index 
1.3920 (estimate)
FEMA 
3891 | 2-OXOPENTANEDIOIC ACID
storage temp. 
2-8°C
solubility 
H2O: soluble0.1g/mL, clear, colorless
form 
Crystalline Powder
pka
2.47(at 25℃)
color 
White to slightly yellow
Odor
Odorless
PH
3.09(1 mM solution);2.36(10 mM solution);1.77(100 mM solution)
Water Solubility 
Soluble in water, methanol and dimethyl sulfoxide.
Merck 
14,5303
JECFA Number
634
BRN 
1705689
InChIKey
KPGXRSRHYNQIFN-UHFFFAOYSA-N
LogP
-2.08 at 25℃
CAS DataBase Reference
328-50-7(CAS DataBase Reference)
NIST Chemistry Reference
2-Oxopentanedioic acid(328-50-7)
EPA Substance Registry System
Pentanedioic acid, 2-oxo- (328-50-7)
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Safety Information

Hazard Codes 
Xi,T
Risk Statements 
37/38-41-36/37/38-23/24/25
Safety Statements 
26-39-45-36/37/39
WGK Germany 
3
TSCA 
Yes
HS Code 
29183000

MSDS

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2-Ketoglutaric acid Usage And Synthesis

Description

2-Ketoglutaric acid also known as α-Ketoglutaric acid (AKG) is a chemical found in the body. It is a ketone derivative of the organic compound glutaric acid. It is important for the proper metabolism of all essential amino acids and the transfer of cellular energy in the citric acid or Krebs cycle. In combination with L-glutamate, AKG can reduce levels of ammonia formed in the brain, muscles, and kidneys, as well as help balance the body’s nitrogen chemistry and prevent nitrogen excess in body tissues and fluids.
α-Ketoglutaric acid is used for kidney disease; intestinal and stomach disorders, including bacterial infections; liver problems; cataracts; and recurring yeast infections. It is also used for improving the way kidney patients receiving hemodialysis treatments process protein.

Chemical Properties

2-Ketoglutaric acid is a white to yellowish crystalline powder. It is easily soluble in water, alcohol, and extremely insoluble in ether. It becomes light gray-yellow when stored for a long time, and is easy to deliquescence.

Uses

2-Ketoglutaric acid has a wide range of applications in the animal feed, food, pharmaceutical and fine chemistry industries. It is used as an intermediate in the kreb's cycle catalyzed by glutamate dehydrogenase enzyme on glutamate. It is also used in dietary supplements to improve protein synthesis.

Definition

ChEBI: 2-oxoglutaric acid is an oxo dicarboxylic acid that consists of glutaric acid bearing an oxo substituent at position 2. It is an intermediate metabolite in Krebs cycle. It has a role as a fundamental metabolite. It derives from a glutaric acid. It is a conjugate acid of a 2-oxoglutarate(1-).

Application

2-Ketoglutaric acid is a derivative of glutaric acid. It plays an important role in the metabolism of microbial cells and It acts as precursor for the synthesis of amino acids and nucleotides. α-ketoglutaric acid along with L-arginine can undergo reduction with sodium cyanoborohydride to form the diastereomers, nopaline and isonopaline. α-ketoglutaric acid can be prepared in 1:1 and 2:1 L-arginine alpha-ketoglutarate for sports nutrition. mainly as an ingredient in sports nutrition drinks.

Preparation

Synthesis of α-ketoglutaric acid: 225 g of triethyl nitrilotricarboxylate and 600 ml of concentrated hydrochloric acid were mixed and left to pass through. It was concentrated by distillation to 140°C, and the residue was crystallized by cooling to obtain 110-112 g of α-ketoglutaric acid with a yield of 92-93%.

General Description

2-Ketoglutaric acid is a 2-oxocarboxylic acid (2-OCA), one of the important intermediates in the Krebs cycle, after isocitrate and before succinyl CoA. It is an important nitrogen transporter and is transaminate along with glutamine to form glutamate. It can be used to differentiate microorganisms based on metabolic properties. It also possesses metabolic properties, decreasing the level of hydrogen peroxide in cell culture.

Flammability and Explosibility

Not classified

Biotechnological Applications

a-Ketoglutaric acid is an intermediate of the tricarboxylic acid cycle and the main compound of amino acid and protein metabolism. This organic acid could be used as building-block chemical for the chemical synthesis of heterocycles, dietary supplement, component of infusion solutions, and wound healing compounds (Otto et al. 2013).

Purification Methods

Crystallise the keto-acid repeatedly from Me2CO/*benzene, EtOAc or ethyl propionate. Dry it in vacuo.[Beilstein 3 IV 1813.]

2-Ketoglutaric acid Preparation Products And Raw materials

Raw materials

2-Ketoglutaric acidSupplier

Changzhou jinhan pharmaceutical technology co., LTD Gold
Tel
13917833665
Email
lyg@world-goldpharma.com
Products Intro
Product Name:a-Ketoglutaric acid
CAS:328-50-7
Purity:纯度:98% Package:1kg, 1吨
Gansu Province Baishixing Pharmaceutical Co.,Ltd Gold
Tel
13668201230
Email
1437493064@qq.com
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Product Name:2-Ketoglutaric acid
CAS:328-50-7
Wuxi Jingyao Bio-Technology Co., Ltd. Gold
Tel
0510-88770633 13961738808
Email
jingyaobiotech@126.com
Products Intro
Product Name:alpha-Ketoglutaric acid
CAS:328-50-7
Purity:99% Package:25kg;1000kg
Hubei XinghengKang Chemical Technology Co., Ltd. Gold
Tel
027-88878869 18162384755
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xhkhu2014@163.com
Products Intro
Product Name:2-Ketoglutaric acid
CAS:328-50-7
Purity:99% Package:200KG
Joyman BIOTECH (Lianyungang) Co., Ltd. Gold
Tel
0518-85817797 18661269107
Email
info@joy-man.com
Products Intro
Product Name:2-Ketoglutaric acid
CAS:328-50-7
Purity:≥98% Package:1千克/RMB 150;25千克