2-AMINO-2-NORBORNANECARBOXYLIC ACID Chemical Properties

Melting point:

>300 °C(lit.)

Boiling point:

295.5±23.0 °C(Predicted)

Density 

1.256±0.06 g/cm3(Predicted)

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

solubility 

Aqueous Acid (Slightly)

form 

Solid

pka

2.58±0.20(Predicted)

color 

White

Water Solubility 

Soluble to 100 mM in water

CAS DataBase Reference

20448-79-7(CAS DataBase Reference)

Safety Information

WGK Germany 

3

MSDS

• Language:English Provider:SigmaAldrich

2-AMINO-2-NORBORNANECARBOXYLIC ACID Usage And Synthesis

Uses

2-Amino-2-norbornanecarboxylic Acid functions in the suppressive effect of I-type amino acid transporter 1 inhibition as therapeutic target on human esophageal squamous cell carcinoma. Also use in the design and preparation of KMH-233, selective and slowly reversible inhibitor of L-type amino acid transporter 1 (LAT1) which potentiates antiproliferative drug efficacy in cancer cells

Definition

ChEBI: 2-Amino-2-norbornanecarboxylic acid is a monoterpenoid.

General Description

2-Amino-2-norbornanecarboxylic acid is a potential large amino acid transporters inhibitor. It may suppress tumor progression and apoptosis.

Biochem/physiol Actions

2-Amino-2-norbornanecarboxylic acid (BCH) is a Na(+)-independent system L specific substrate used with other system specific substrates such as the system A specific substrate α-(methylamino) isobutyric acid and system N specific substrate L-glutamic acid gamma-monohydroxamate to help identify, differentiate and characterize amino acid transport systems in cells.

storage

Store at RT

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