Basic information Safety Supplier Related

L-1,2,3,4-TETRAHYDRONORHARMAN-3-CARBOXYLIC ACID

Basic information Safety Supplier Related

L-1,2,3,4-TETRAHYDRONORHARMAN-3-CARBOXYLIC ACID Basic information

Product Name:
L-1,2,3,4-TETRAHYDRONORHARMAN-3-CARBOXYLIC ACID
Synonyms:
  • L-TRYPTOLINE-3-CARBOXYLIC ACID
  • H-TPI-OH
  • H-THNH(3)-OH
  • L-2,3,4-TETRAHYDRO-BETA-CARBOLINE-3-CARBOXYLIC ACID
  • L-1,2,3,4-TETRAHYDRO-9H-PYRIDO[3,4-B]INDOLE-3-CARBOXYLIC ACID
  • L-1,2,3,4-TETRAHYDRONORHARMAN-3-CARBOXYLIC ACID
  • 1,2,3,4-TETRAHYDRONORHARMAN-L-3-CARBOXYLIC ACID
  • RARECHEM BK PT 0088
CAS:
42438-90-4
MF:
C12H12N2O2
MW:
216.24
Product Categories:
  • Phenylalanine analogs and other aromatic alpha amino acids
Mol File:
42438-90-4.mol
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L-1,2,3,4-TETRAHYDRONORHARMAN-3-CARBOXYLIC ACID Chemical Properties

Melting point:
289 °C (dec.)(lit.)
Boiling point:
485.0±45.0 °C(Predicted)
Density 
1.377±0.06 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
soluble1.5mg/mL, clear (Solvent: 0.1N HCl:DMSO (1:1); warmed)
pka
2.28±0.20(Predicted)
form 
powder
color 
white to beige
optical activity
[α]/D -57 to -67°, c = 1 (in MeOH:1N HCl (1:1))
InChIKey
FSNCEEGOMTYXKY-JTQLQIEISA-N
CAS DataBase Reference
42438-90-4(CAS DataBase Reference)
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Safety Information

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
HazardClass 
IRRITANT

MSDS

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L-1,2,3,4-TETRAHYDRONORHARMAN-3-CARBOXYLIC ACID Usage And Synthesis

Chemical Properties

White to off-white powder

Biochem/physiol Actions

TNCA is a tryptophan derivative that binds the parathyroid Ca2+-sensing receptor (CaSR) extracellular domain (ECD) hinge region between two globular subdomains and acts as a high-affinity CaSR ligand (CaSRL) with co-agonist activity. TNCA is shown to potentiate both Mg++- and Ca++-evoked cellular calcium response (0.1-0.5 mM), as well as Mg++-evoked cellular ERK1/2 phosphorylation in CaSR-expressing HEK293 cells (0.5 mM). AC-265347 (Cat. No. SML0129), on the other hand, is a calcimimetic that functions as a CaSR agonist.

L-1,2,3,4-TETRAHYDRONORHARMAN-3-CARBOXYLIC ACIDSupplier

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