2,3,4-Trihydroxybenzaldehyde Chemical Properties

Melting point:

159-161 °C (lit.)

Boiling point:

237.46°C (rough estimate)

Density 

1.3725 (rough estimate)

refractive index 

1.6400 (estimate)

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

solubility 

DMSO, Methanol

form 

Powder

pka

7.41±0.23(Predicted)

color 

Light brown to beige-brown

Water Solubility 

1.541g/L at 25℃

Sensitive 

Air Sensitive

BRN 

2328658

LogP

1.25

CAS DataBase Reference

2144-08-3(CAS DataBase Reference)

EPA Substance Registry System

Benzaldehyde, 2,3,4-trihydroxy- (2144-08-3)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-37/39-36

WGK Germany 

2

RTECS 

CU8439800

TSCA 

Yes

HS Code 

29124990

MSDS

• Language:English Provider:2,3,4-Trihydroxybenzaldehyde
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

2,3,4-Trihydroxybenzaldehyde Usage And Synthesis

Description

2,3, 4-trihydroxybenzaldehyde is an essential intermediate of the antiparkinson drug benserazide, which is a peripheral dopa decarboxylase inhibitor, usually benserazide: the L-dopa is prepared into a compound preparation at a ratio of 1:4, and has a remarkable effect of treating the Parkinson's disease.

Chemical Properties

light brown to beige-brown powder

Uses

2,3,4-Trihydroxybenzaldehyde is a phenolic benzaldehyde with antibacterial activity.

Uses

2,3,4-Trihydroxybenzaldehyde has been used in the preparation of 1,5-dimethyl-2-phenyl-4-[(1E)-(2,3,4-trihydroxybenzylidene)amino]-1H-pyrazol-3(2H)-one.

General Description

Antimicrobial activity of carbohydrazone derived from 2,3,4-trihydroxybenzaldehyde against bacteria and fungi has been investigated. 2,3,4-trihydroxybenzaldehyde forms Schiff bases via [1+1] condensation with anthranilic acid.

Synthesis

The method for synthesizing 2,3, 4-trihydroxybenzaldehyde is shown as follows.
This method takes pyrogallol as an initial raw material. It comprises three steps of phenolic hydroxyl protection, formylation, and deprotection: protecting two adjacent phenolic hydroxyl groups in the pyrogallol to obtain 4-hydroxybenzo[d][1,3]dioxol-2-one, then performing formylation to obtain 7-hydroxy-2-oxobenzo[d][1,3]dioxole-4-carbaldehyde, and finally removing a protecting group to get a target 2,3,4-trihydroxybenzaldehyde.

2,3,4-Trihydroxybenzaldehyde(2144-08-3)Related Product Information

• Protocatechualdehyde
• Salicylaldehyde
• Benzaldehyde
• 3-Hydroxybenzaldehyde
• 2,3,4-Trimethoxybenzaldehyde
• 4-Hydroxybenzaldehyde
• 2-(Trifluoromethyl)benzaldehyde
• 3-(Trifluoromethyl)benzaldehyde
• 2,3-Dihydroxybenzaldehyde
• p-Anisaldehyde
• 2,3,4-TRIMETHOXYPHENYLACETIC ACID
• TriMethopriM IMpurity C
• 3-Iodobenzyl bromide
• 3-Anilino-2-(3,4,5-triMethoxybenzyl)acrylonitrile, (Mixture of cis/trans isoMers)
• Trimethoprim Related Compound B (25 mg) (2,4-diaminopyrimidin-5-yl)(3,4,5-trimethoxyphenyl)methanone) (AS)
• 1,4-Bis(2,3,4-triMethoxybenzyl)piperazine
• 4-[(2,3,4-TriMethoxyphenyl)Methyl]-1-piperazinecarboxylic Acid Ethyl Ester
• 1-(3,4,5-TRIMETHOXY-BENZYL)-PIPERAZINE