Cinnamamide Chemical Properties

Melting point:

148-150 °C(lit.)

Boiling point:

267.28°C (rough estimate)

Density 

1.1135 (rough estimate)

refractive index 

1.5450 (estimate)

storage temp. 

Sealed in dry,Room Temperature

solubility 

DMSO (Slightly), Methanol (Slightly)

form 

Crystalline Powder

pka

15?+-.0.50(Predicted)

color 

Off-white to beige

BRN 

2040577

InChIKey

APEJMQOBVMLION-VOTSOKGWSA-N

CAS DataBase Reference

621-79-4(CAS DataBase Reference)

NIST Chemistry Reference

Benzylidene acetamide(621-79-4)

EPA Substance Registry System

2-Propenamide, 3-phenyl- (621-79-4)

Safety Information

Hazard Codes 

Xn

Risk Statements 

22

Safety Statements 

36

WGK Germany 

3

RTECS 

GD6853000

TSCA 

Yes

HazardClass 

IRRITANT

HS Code 

29242990

MSDS

• Language:English Provider:Cinnamamide
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

Cinnamamide Usage And Synthesis

Chemical Properties

OFF-WHITE TO BEIGE CRYSTALLINE POWDER

Uses

Cinnamamide, a non-lethal repellent, deters feeding by a wide range of avian species.

Definition

ChEBI: The simplest member of the class of cinnamamides that consists of acrylamide bearing a phenyl substituent at the 3-position.

Biological Activity

Cinnamamide is an amide form of of trans-cinnamic acid and a metabolite of Streptomyces. Cinnamamide exhibits low cytotoxicity against BEL-7402 human hepatoma cells and HT-1080 fibrosarcoma cells and inhibits cell growth (IC50s = 1.94 and 1.29 mM, respectively). In vivo, cinnamamide (40 and 100 mg/kg, i.p.) reduces tumor weight in a mouse model of C26 murine colon carcinoma. Cinnamamide (75 and 150 mg/kg, i.p.) also reduces tumor weight in a mouse model of murine hepatoma 22 by 42% and 49%, respectively, without reducing body weight when delivered one or three days following tumor implantation. When presented with cinnamamide-treated food at a concentration of 0.8% w/w, house and wood mice food consumption is reduced to 32% and 17% of pretreatment levels, respectively, however, wood mouse consumption returns to pretrial levels by day two.

Cinnamamide(621-79-4)Related Product Information

• Boc-D-Glutamine
• N,N'-Methylenebisacrylamide
• N,N-Dimethylformamide
• Nicotinamide
• Polyamide
• Polyacrylamide
• Formamide
• Acrylamide
• Cinnamic acid
• Methyl cinnamate
• Cinnamonitrile
• Cinnamyl alcohol
• Benzyl cinnamate
• ALLYL CINNAMATE
• Ethyl cinnamate
• Cinnamyl chloride
• N-(4-bromophenyl)cinnamamide
• 4-Chlorocinnamamide