FIBRONECTIN TYPE III CONNECTING SEGMENT FRAGMENT 1-25
FIBRONECTIN TYPE III CONNECTING SEGMENT FRAGMENT 1-25 Basic information
- Product Name:
- FIBRONECTIN TYPE III CONNECTING SEGMENT FRAGMENT 1-25
- Synonyms:
-
- FIBRONECTIN TYPE III CONNECTING SEGMENT FRAGMENT 1-25
- FIBRONECTIN TYPE III CONNECTING SEGMENT FRAGMENT 1-
- CS1 peptide
- Fibronectin connecting segment 1
- L-Threonine, L-alpha-aspartyl-L-alpha-glutamyl-L-leucyl-L-prolyl-L-glutaminyl-L-leucyl-L-valyl-L-threonyl-L-leucyl-L-prolyl-L-histidyl-L-prolyl-L-asparaginyl-L-leucyl-L-histidylglycyl-L-prolyl-L-alpha-glutamyl-L-isoleucyl-L-leucyl-L-alpha-aspartyl-L-valyl-L-prolyl-L-seryl-
- L-Threonine, L-α-aspartyl-L-α-glutamyl-L-leucyl-L-prolyl-L-glutaminyl-L-leucyl-L-valyl-L-threonyl-L-leucyl-L-prolyl-L-histidyl-L-prolyl-L-asparaginyl-L-leucyl-L-histidylglycyl-L-prolyl-L-α-glutamyl-L-isoleucyl-L-leucyl-L-α-aspartyl-L-valyl-L-prolyl-L-seryl-
- Fibronectin Type III Connecting Segment Fragment 1-25 >=90% (HPLC)
- CAS:
- 107978-77-8
- MF:
- C123H195N31O39
- MW:
- 2732.05
- Product Categories:
-
- Extracellular Matrix Peptides and ProteinsProteins and Derivatives
- Cell Signaling Enzymes
- ECM ProteinsCytoskeleton and Extracellular Matrix
- Extracellular Matrix
- Extracellular Matrix Peptides (ECM)
- Fibronectin Fragments and Analogs
- FibronectinPeptides for Cell Biology
- Matrix Metalloproteinases Products
- Structural Proteins
- Mol File:
- 107978-77-8.mol
FIBRONECTIN TYPE III CONNECTING SEGMENT FRAGMENT 1-25 Chemical Properties
- Boiling point:
- 2583.2±65.0 °C(Predicted)
- Density
- 1.338±0.06 g/cm3(Predicted)
- storage temp.
- −20°C
- form
- powder
- biological source
- synthetic (organic)
- Sequence
- Asp-Glu-Leu-Pro-Gln-Leu-Val-Thr-Leu-Pro-His-Pro-Asn-Leu-His-Gly-Pro-Glu-Ile-Leu-Asp-Val-Pro-Ser-Thr
MSDS
- Language:English Provider:SigmaAldrich
FIBRONECTIN TYPE III CONNECTING SEGMENT FRAGMENT 1-25 Usage And Synthesis
Uses
Fibronectin Type III Connecting Segment Fragment 1-25 is a peptide that is responsible for melanoma cell adhesion, and plays an important role in development of the peripheral nervous system in chicken[1][2].
Biological Activity
Fibronectin Type III Connecting Segment (IIICS) is responsible for melanoma cell adhesion. It is the predominant binding site of integrin α4β1, which is mediated through the aspartic acid residue present at position 21. Studies in chicken show th at alternative splicing in this region during development of the peripheral nervous system, is essential for the control cell-cell adhesion.
References
[1] A Komoriya, et al. The minimal essential sequence for a major cell type-specific adhesion site (CS1) within the alternatively spliced type III connecting segment domain of fibronectin is leucine-aspartic acid-valine. J Biol Chem. 1991 Aug 15;266(23):15075-9. PMID:1869542
[2] M J Humphries, et al. Neurite extension of chicken peripheral nervous system neurons on fibronectin: relative importance of specific adhesion sites in the central cell-binding domain and the alternatively spliced type III connecting segment. J Cell Biol. 1988 Apr;106(4):1289-97. DOI:10.1083/jcb.106.4.1289
FIBRONECTIN TYPE III CONNECTING SEGMENT FRAGMENT 1-25Supplier
- Tel
- 17705183659
- sales@njleonbiotech.com
- Tel
- 025-58361106-805 15951641583
- zhao.xu@njpeptide.com
- Tel
- meitaochem@126.com
- meitaochem@126.com
- Tel
- 021-58432009 400-005-6266
- marketing1@energy-chemical.com
- Tel
- 0571-85350119 15888826472
- bptsales@163.com