2-Bromo-4-fluoroaniline Chemical Properties

Melting point:

41

Boiling point:

221 °C (lit.)

Density 

1.67 g/mL at 25 °C (lit.)

refractive index 

n20/D 1.583(lit.)

Flash point:

220 °F

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

pka

2.60±0.10(Predicted)

form 

Liquid

color 

Clear yellow-brown

Specific Gravity

1.670

BRN 

2802562

InChI

InChI=1S/C6H5BrFN/c7-5-3-4(8)1-2-6(5)9/h1-3H,9H2

InChIKey

YLMFXCIATJJKQL-UHFFFAOYSA-N

SMILES

C1(N)=CC=C(F)C=C1Br

CAS DataBase Reference

1003-98-1(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi,T

Risk Statements 

36/37/38

Safety Statements 

26-37/39

RIDADR 

UN2810

WGK Germany 

3

Hazard Note 

Toxic

HazardClass 

6.1

PackingGroup 

III

HS Code 

29214200

MSDS

• Language:English Provider:2-Bromo-4-fluoroaniline
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

2-Bromo-4-fluoroaniline Usage And Synthesis

Uses

2-Bromo-4-fluoroaniline is an organic compound that is an aniline derivative. It is mainly used as an organic synthesis reagent in experimental research.

Chemical Properties

Clear yellow-brown liquid

General Description

2-Bromo-4-fluoroaniline is an aryl fluorinated building block.

Synthesis

The general procedure for the synthesis of 2-bromo-4-fluoroaniline from 4-fluoroaniline was as follows: 200 mL of distilled N,N-dimethylformamide (DMF) and 4-fluoroaniline (8.64 mL, 58.13 mmol) were added to a two-necked flask equipped with a stirring device. N-bromosuccinimide (11.4 g, 63.95 mmol) dissolved in DMF was added slowly and dropwise with stirring. After completion of the reaction, extraction was carried out using dichloromethane (CH2Cl2). The product was purified by column chromatography (eluent ratio of ethyl acetate: n-hexane = 1:4), and the target product 2-bromo-4-fluoroaniline was finally obtained in 95% yield.

References

[1] Patent: KR2018/50795, 2018, A. Location in patent: Paragraph 0134; 0135; 0152-0154
[2] Tetrahedron Letters, 2000, vol. 41, # 13, p. 2083 - 2085
[3] Journal of the American Chemical Society, 2011, vol. 133, # 18, p. 6868 - 6870
[4] Chemistry - A European Journal, 2011, vol. 17, # 49, p. 13665 - 13669
[5] Tetrahedron Letters, 2014, vol. 55, # 38, p. 5338 - 5341

2-Bromo-4-fluoroaniline(1003-98-1)Related Product Information

• 4-(Trifluoromethoxy)aniline
• 2-Aminobenzotrifluoride
• 4-Fluoroaniline
• 2-Bromoaniline
• 3-Fluoroaniline
• Diphenylamine
• Ethyl bromodifluoroacetate
• 2-Fluoroaniline
• 2-BROMO-6-CHLORO-4-FLUOROANILINE
• 2'-Bromo-4'-fluoroacetanilide
• 2,4,5-TRIFLUORO-6-BROMOANILINE
• 2-Bromo-4,6-difluoroaniline
• 2-BROMO-4,6-DIFLUOROPHENYL ISOCYANATE
• 2-BROMO-4-FLUOROPHENYL ISOTHIOCYANATE
• 2-Bromo-4-fluoronitrobenzene
• 2-BROMO-4,5,6-TRIFLUOROANILINE
• Bromine
• 2,6-DIBROMO-4-FLUOROPHENYL ISOCYANATE