4-Bromo-3-chloroanisole Chemical Properties

Boiling point:

129-132°C

Density 

1.564±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

form 

liquid

color 

Clear, colourless

CAS DataBase Reference

50638-46-5(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xn

Risk Statements 

22-51

Hazard Note 

Harmful

HS Code 

2909309090

4-Bromo-3-chloroanisole Usage And Synthesis

Chemical Properties

Light yellow liquid

Synthesis

GENERAL METHOD: To a reaction tube containing N-bromosuccinimide (NBS, 1.5 eq, 0.3 mmol), catalyst (10 mol%, 0.02 mmol) and acetonitrile (CH3CN, 1.0 mL) was added 3-chloroanisole (1a, 0.2 mmol). The reaction mixture was stirred for 12 h at room temperature in a dark environment. Upon completion of the reaction, the reaction was quenched by the addition of saturated sodium thiosulfate (Na2S2O3) aqueous solution (2 mL). The reaction mixture was extracted with ethyl acetate (3.5 mL). The organic phases were combined, washed with brine (10 mL), dried over anhydrous sodium sulfate (Na2SO4), and filtered through a diatomaceous earth pad. The filtrate was concentrated under reduced pressure and the residue was purified by rapid chromatography on a silica gel column using petroleum ether/dichloromethane (5:1, v/v) as eluent to give the target product 4-bromo-3-chloroanisole (2a).

References

[1] Synthetic Communications, 2007, vol. 37, # 2, p. 323 - 328
[2] Tetrahedron, 2017, vol. 73, # 50, p. 7105 - 7114
[3] Journal of the Serbian Chemical Society, 2011, vol. 76, # 5, p. 685 - 692
[4] Monatshefte fur Chemie, 2013, vol. 144, # 2, p. 179 - 181

4-Bromo-3-chloroanisole(50638-46-5)Related Product Information

• 2-Bromoanisole
• Anisole
• 4'-Bromopropiophenone
• 4-Bromo-3-fluoroanisole
• Dimefluthrin
• Bromoxynil octanoate
• 2-Bromofluorobenzene
• 1-Methoxy-2-propyl acetate
• Bromoxynil
• Demosan
• 4-Bromoanisole
• 2-Chloroanisole
• 1,2,4-Trichlorobenzene
• Artemether
• 3-Bromoanisole
• Chlorphenamine maleate
• Dimethyl ether
• 4-Bromo-3-nitroanisole