Basic information The intermediate of Vitamin E Chemical Properties Uses Production method Safety Supplier Related
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Trimethylhydroquinone

Basic information The intermediate of Vitamin E Chemical Properties Uses Production method Safety Supplier Related

Trimethylhydroquinone Basic information

Product Name:
Trimethylhydroquinone
Synonyms:
  • 3,6-dihydroxypseudocumol
  • 4-Benzenediol,2,3,5-trimethyl-1
  • -Cumoquinol
  • Hydroquinone, trimethyl-
  • Pseudocumohydroquinone
  • psi-Cumohydroquinone
  • tmhq
  • trimethyl-hydroquinon
CAS:
700-13-0
MF:
C9H12O2
MW:
152.19
EINECS:
211-838-3
Product Categories:
  • Building Blocks
  • Chemical Synthesis
  • Intermediates of Seratrodast
  • Organic Building Blocks
  • Oxygen Compounds
  • Polyols
  • bc0001
Mol File:
700-13-0.mol
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Trimethylhydroquinone Chemical Properties

Melting point:
169-172 °C (lit.)
Boiling point:
295 °C (759.8513 mmHg)
Density 
0.9595 (rough estimate)
vapor pressure 
0-0.017Pa at 20-50℃
refractive index 
1.4464 (estimate)
Flash point:
191 °C
storage temp. 
Inert atmosphere,Room Temperature
solubility 
methanol: 0.1 g/mL, clear
pka
11.28±0.28(Predicted)
form 
Crystalline Powder
color 
Beige
Water Solubility 
2 g/L (20 ºC)
BRN 
1909183
Stability:
Stable. Combustible. Incompatible with strong oxidizing agents.
InChIKey
AUFZRCJENRSRLY-UHFFFAOYSA-N
LogP
3.32 at 25℃
Dissociation constant
10.8-12.9
CAS DataBase Reference
700-13-0(CAS DataBase Reference)
NIST Chemistry Reference
Trimethylhydroquinone(700-13-0)
EPA Substance Registry System
1,4-Benzenediol, 2,3,5-trimethyl- (700-13-0)
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Safety Information

Hazard Codes 
Xn,N
Risk Statements 
20-37/38-41-43-50/53
Safety Statements 
24-26-37/39-60-61
RIDADR 
UN 3077 9/PG 3
WGK Germany 
2
RTECS 
MX7820000
9-23
TSCA 
Yes
HazardClass 
9
PackingGroup 
III
HS Code 
29072990

MSDS

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Trimethylhydroquinone Usage And Synthesis

The intermediate of Vitamin E

Trimethylhydroquinone and isophytol are two intermediate in the synthesis of vitamin E, currently trimethylhydroquinone in world market is mainly produced by BASF and Roche, it can not meet the needs of vitamin E. The 2,3,5-trimethyl hydroquinone of China is put into operation by only a few companies, China has become the world's second largest feed production country, if the amount of vitamin E in animal feed reach the average level of foreign words, the annual consumption vitamin E is nearly 2000t. According to Chinese feed industry planning, the amount of feed demand synthetic vitamin E is about 2500t in 2005. Furthermore, the needs of vitamin E in pharmaceutical, food, cosmetics and other needs for vitamin E will grow steadily in the future. So in the last ten years, or even 20 years, the future market 2,3,5-trimethyl hydroquinone can not be not saturated. The development of this project has broad application prospects.
Vitamin E is not only used as a medicine, feed, food, cosmetic additives, but also get more and more applications in industry, such as industrial antioxidants, polyolefin non-toxic, biodegradable stabilizer. A sharp increase in domestic and international market demand for vitamin E is present. The naturally occurring vitamin E is very limited, so timely start-up and expansion of production of vitamin E will bring better economic benefits.
The above information is edited by the chemicalbook of Wang Xiaodong.

Chemical Properties

It is crystalline solid. When heated, it can sublimate, when esposed to moisture, it can turn black easily. It can be slightly soluble in water, soluble in ethyl alcohol, insoluble in petroleum ether. Melting point is 173℃.

Uses

The product is main ring of vitamin E, it can condensation with isophytol to get vitamin E.
Organic intermediates, pharmaceutical intermediates, it can be used for the synthesis of VE.

Production method

By sulfonation, nitration, reduction, oxidation 1,2,4-trimethylbenzene can get 2,3,5-trimethyl benzoquionone ([935-92-2]). 2,3,5-trimethyl benzoquionone is yellow needle crystallization, melting point is 32℃ (38-29.5℃), the boiling point is 53℃(53Pa). Said step of products are generally to obtain a solution of petroleum ether or gasoline. In 2,3,5-trimethyl gasoline solution (petroleum ether), hydrosulfite solution is added with stirring, stir at room temperature for 3h, then filter, the cake should be washed with 0.5% hydrosulfite solution, and then dry to get trimethyl hydroquinone.

Chemical Properties

off-white, tan or orange powder

Uses

Trimethylhydroquinone is used for synthesizing vitamin E and used as medical intermediate.

Uses

Trimethylhydroquinone is a key precursor for the synthesis of tocopherols (vitamin E) and (±)-madindolines.

Definition

ChEBI: 2,3,5-trimethylhydroquinone is a member of the class of hydroquinones that is hydroquinone substituted by methyl groups at positions 2, 3 and 5. It is a member of hydroquinones and a methylbenzene.

Synthesis Reference(s)

Chemical and Pharmaceutical Bulletin, 16, p. 378, 1968 DOI: 10.1248/cpb.16.378

Safety Profile

Experimental reproductive effects. When heated to decomposition it emits acrid smoke and irritating fumes.

Purification Methods

Recrystallise the hydroquinone from water, under anaerobic conditions. [Beilstein 6 H 931, 6 IV 5997.]

Trimethylhydroquinone Preparation Products And Raw materials

Preparation Products

Raw materials

TrimethylhydroquinoneSupplier

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