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GLYCODEOXYCHOLIC ACID

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GLYCODEOXYCHOLIC ACID Basic information

Product Name:
GLYCODEOXYCHOLIC ACID
Synonyms:
  • deoxycholylglycine
  • glycodeoxy-5-beta-cholan-24-oicaci
  • glykodesoxycholsaeure
  • n-((3-alpha,5-beta,12-alpha)-3,12-dihydroxy-24-oxocholan-24-yl)-glycine
  • n-(3-alpha,12-alpha-dihydroxy-5-beta-cholan-24-yl)-glycin
  • 3α,12α-Dihydroxy-5β-cholanoic acid N-(carboxymethyl)amide
  • N-(3α,12α-Dihydroxy-24-oxocholan-24-yl)glycine
  • 2-[4-[(3R,5R,10R,12S,13R)-3,12-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentylamino]acetic acid
CAS:
360-65-6
MF:
C26H43NO5
MW:
449.63
Mol File:
360-65-6.mol
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GLYCODEOXYCHOLIC ACID Chemical Properties

Melting point:
184 °C
Boiling point:
655.6±50.0 °C(Predicted)
Density 
1.162±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
Acetonitrile (Slightly), Ethanol (Slightly), Methanol (Slightly)
form 
Solid
pka
pKa 3.87±0.06(H2O,t = 25.0±0.1,I=0.00) (Uncertain)
color 
White to Off-White
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Safety Information

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26
WGK Germany 
3
RTECS 
MB9670000
10
Toxicity
mouse,LD50,intravenous,140mg/kg (140mg/kg),Arzneimittel-Forschung. Drug Research. Vol. 20, Pg. 323, 1970.
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GLYCODEOXYCHOLIC ACID Usage And Synthesis

Uses

Glycodeoxycholic Acid is a bile acid that induces severe pancreatitis in rats.

Definition

ChEBI: Glycodeoxycholic acid is a bile acid glycine conjugate of deoxycholic acid. It has a role as a human metabolite. It is functionally related to a deoxycholic acid. It is a conjugate acid of a glycodeoxycholate.

Purification Methods

Glycodeoxycholic acid recrystallises from H2O or aqueous EtOH with 1 mol of H2O and is dried at 100o in vacuo. Its solubility in EtOH is ~5%. [UV: Lindstedt & Sj.vall Acta Chem Scand 11 421 1957.] The Na salt recrystallises from EtOH/Et2O with m 245-250o and [] D23 +41.2o (c 1, H2O) [Wieland Hoppe Seyler's Z Physiol Chem 106 181 1919, Cortese J Am Chem Soc 59 2532 1937]. [Beilstein 10 IV 1611.]

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