1-(3-Pyridyl)-3-(dimethylamino)-2-propen-1-one Chemical Properties

Melting point:

86-88

Boiling point:

281.4±36.0 °C(Predicted)

Density 

1.070±0.06 g/cm3(Predicted)

vapor pressure 

0.049Pa at 20℃

storage temp. 

Inert atmosphere,Room Temperature

solubility 

Soluble in chloroform and dichloromethane.

form 

powder to crystal

pka

6.19±0.70(Predicted)

color 

Light yellow to Brown

InChIKey

MZLRFUCMBQWLNV-FNORWQNLSA-N

LogP

0.26 at 20℃ and pH7.2

Surface tension

71.8mN/m at 1.008g/L and 20℃

CAS DataBase Reference

55314-16-4(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi,Xn

Risk Statements 

22-36/37/38

Safety Statements 

26-36/37/39

HazardClass 

IRRITANT

HS Code 

29333990

1-(3-Pyridyl)-3-(dimethylamino)-2-propen-1-one Usage And Synthesis

Description

1-(3-Pyridyl)-3-(dimethylamino)-2-propen-1-one can be used in the synthesis of imatinib and nilotinib (AMN107), a compound currently in multiple Phase II/III clinical trials for chronic granulocytic leukaemia. Imatinib, on the other hand, is a cancer growth blocker known as a tyrosine kinase inhibitor (TKI), which is used to treat a wide range of leukaemias, myelodysplastic/myeloproliferative disorders, systemic mastocytosis, eosinophilia syndromes, raised dermal fibrosarcoma and gastrointestinal mesenchymal tumours.

Chemical Properties

Off-White Solid

Uses

Rasagiline intermediate

Uses

3-Dimethylamino-1-(3-pyridyl)-2-propen-1-one is used ads pharmaceutical intermediate, an imatinib intermediate.

Solubility in organics

1-(3-Pyridyl)-3-(dimethylamino)-2-propen-1-one is soluble in Chloroform and Dichloromethane.

1-(3-Pyridyl)-3-(dimethylamino)-2-propen-1-one(55314-16-4)Related Product Information

• 3-Dimethylaminopropylamine
• 4-Dimethylaminobenzaldehyde
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• N-Desmethyl Imatinib
• N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidineamine
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• 1-(4,6-dibroMo-3-fluorothieno[3,4-b]thiophen-2-yl)-2ethylhexan-1-one
• 1-(2,3-Dichlorophenyl)piperazine hydrochloride
• N-DESMETHYL IMATINIB
• 4-Chloromethyl-N-[4-methyl-3-[[4-(pyridin-3-yl)pyrimidin-2-yl]amino]phenyl]benzamide
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• Imatinib Meta-methyl-piperazine Impurity
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