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Cinobufotalin

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Cinobufotalin Basic information

Product Name:
Cinobufotalin
Synonyms:
  • cinobufotalin venom toad
  • Cinobufotalin std.
  • 5BETA,20[22]-BUFADIENOLIDE-14,15BETA-EPOXY-3BETA,5ALPHA,16BETA-TRIOL 16-ACETATE
  • 14,15-beta-epoxy-3-beta,5,16-beta-trihydroxy-22-dienolid16-5-beta-bufa-2
  • CINOBUFOTALIN(RG)
  • 14,15b-Epoxy-3b,5a,16b-trihydroxy-5b,20(22)-bufadienolide 16-acetate
  • 5β,20(22)-Bufadienolide-14,15β-epoxy-3β,5α,16β-triol 16-acetate, 14,15β-Epoxy-3β,5α,16β-trihydroxy-5β,20(22)-bufadienolide 16-acetate
  • 14,15-Epoxy-14H-cyclopenta[a]phenanthrene, bufa-20,22-dienolide deriv.
CAS:
1108-68-5
MF:
C26H34O7
MW:
458.54
Mol File:
1108-68-5.mol
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Cinobufotalin Chemical Properties

Melting point:
259-262°
alpha 
D20 +11°
Boiling point:
627.3±55.0 °C(Predicted)
Density 
1.34±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMF: 10 mg/ml; DMF:PBS (pH 7.2) (1:1): 0.5 mg/ml; DMSO: 5 mg/ml; Ethanol: 5 mg/ml
pka
14.67±0.70(Predicted)
form 
White to off-white solid.
CAS DataBase Reference
1108-68-5
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Safety Information

Hazard Codes 
T+
Risk Statements 
26/27/28
Safety Statements 
22-36/37/39-45
RIDADR 
UN 2811 6.1/PG 1
WGK Germany 
3
RTECS 
EI2991000
HazardClass 
6.1(a)
PackingGroup 
II
Toxicity
cat,LD50,intravenous,200ug/kg (0.2mg/kg),"Die Herzwirksamen Glykoside," Baumgarten, G., and W. Forster, Leipzig, Ger. Dem. Rep., VEB Georg Thieme, 1963Vol. -, Pg. 189, 1963.

MSDS

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Cinobufotalin Usage And Synthesis

Description

Cinobufacin is an indole-type total alkaloid extracted from the dried toad skin of Chinese toad, which has the functions of clearing away heat and detoxifying, reducing swelling and pain, promoting blood circulation and removing blood stasis, softening and dispelling knots.

Application

Cinobufacin can be used for a variety of middle and advanced tumors (lung cancer, breast cancer, cervical cancer, digestive system tumors such as primary liver cancer, gastric cancer, colon cancer, etc.), chronic hepatitis B, especially for chronic hepatitis B virus carriers. Especially prominent.

Side effects

For individual patients, if the dosage is too large or the interval between two administrations is less than 6 to 8 hours, chills and fever may occur about 30 minutes after administration; a small number of patients have local irritation or phlebitis after long-term intravenous infusion, which will slow down the infusion rate. Very few patients may also appear urticaria, dermatitis and so on.

CinobufotalinSupplier

Nanjing Endesa Bio-tech Co., Ltd. Gold
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Chembest Research Laboratories Limited
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China Langchem Inc.
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Dalian Meilun Biotech Co., Ltd.
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Chengdu Biopurify Phytochemicals Ltd.
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+86-028-82633397 18982077548
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