20-HYDROXY PROSTAGLANDIN F2ALPHA Chemical Properties

solubility 

10 mM Na2CO3: >6.5 mg/ml (from PGF2a); DMF: >100 mg/ml (from PGF2a); DMSO: >100 mg/ml (from PGF2a); Ethanol: >100 mg/ml (from PGF2a); PBS pH 7.2: >10 mg/ml (from PGF2a)

20-HYDROXY PROSTAGLANDIN F2ALPHA Usage And Synthesis

Description

20-hydroxy Prostaglandin F_2α (20-hydroxy PGF_2α) is the ω-oxidation product of PGF_2α. Cultured type II alveolar cells from pregnant rabbits metabolize exogenous PGF_2α via microsomal cytochrome P450 ω-oxidation, producing 20-hydroxy PGF_2α and its 15-hydroxy PGDH metabolites. Cells from male rabbits exhibit only the 15-hydroxy PGDH pathway.¹

Uses

20-hydroxy Prostaglandin F2α (20-hydroxy PGF2α) is the ω-oxidation product of PGF2α. Cultured type II alveolar cells from pregnant rabbits metabolize exogenous PGF2α via microsomal cytochrome P450 ω-oxidation, producing 20-hydroxy PGF2α and its 15-hydroxy PGDH metabolites. Cells from male rabbits exhibit only the 15-hydroxy PGDH pathway.

Definition

ChEBI: 20-Hydroxy-PGF2alpha is a prostanoid.

References

1. Devereux, T.R., Fouts, J.R., and Eling, T.E. Metabolism of prostaglandin PG-F_2α by freshly isolated alveolar type II cells from lungs of adult male or pregnant rabbits Prostaglandins Leukot. Med. 27,43-52(1987).

20-HYDROXY PROSTAGLANDIN F2ALPHA(57930-92-4)Related Product Information

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