Dimethyl adipate Chemical Properties

Melting point:

8 °C (lit.)

Boiling point:

109-110 °C/14 mmHg (lit.)

Density 

1.062 g/mL at 20 °C (lit.)

vapor pressure 

0.2 mm Hg ( 20 °C)

refractive index 

n20/D 1.428(lit.)

FEMA 

4472 | DIMETHYL ADIPATE

Flash point:

225 °F

storage temp. 

Store below +30°C.

solubility 

<1g/l

form 

Liquid

color 

Clear

Odor

at 100.00 %. mild nutty

Odor Type

nutty

explosive limit

0.81-8.1%(V)

Water Solubility 

Miscible with alcohols and ether. Immiscible with water.

Merck 

14,162

JECFA Number

1964

BRN 

1707443

Stability:

Stable. Combustible. Incompatible with strong oxidizing agents, acids, bases reducing agents.

InChIKey

UDSFAEKRVUSQDD-UHFFFAOYSA-N

LogP

1.4 at 22℃

CAS DataBase Reference

627-93-0(CAS DataBase Reference)

NIST Chemistry Reference

Hexanedioic acid, dimethyl ester(627-93-0)

EPA Substance Registry System

Dimethyl adipate (627-93-0)

Safety Information

Safety Statements 

24/25

WGK Germany 

1

RTECS 

AV1645000

Autoignition Temperature

680 °F

TSCA 

Yes

HS Code 

29171290

Hazardous Substances Data

627-93-0(Hazardous Substances Data)

Toxicity

LD50 orally in Rabbit: 8191 mg/kg LD50 dermal Rabbit > 2250 mg/kg

MSDS

• Language:English Provider:Dimethyl hexanedioate
• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

Dimethyl adipate Usage And Synthesis

Description

Dimethyl adipate (DMA) is a colourless and flammable liquid. It is soluble in alcohol and ether but sparingly soluble in water. DMA is incompatible with strong oxidising agents, and on decomposition, it emits carbon monoxide, irritating and toxic fumes and gases, and carbon dioxide. DMA reacts with acids, alkalis, and strong oxidants. DMA is synthesised by the esterification of adipic acid. DMA is part of a dibasic ester (DBE) blend used as a major ingredient in several paint strippers, and the DBE blends used in paint stripping formulations contain a major portion (about 90%) of DMA. DMA is used as a chemical intermediate (polymers, agrochemicals), cellulose resins, a speciality solvent (inks, coatings, adhesives), and an emollient and can also be utilised as a paint remover and plasticiser.

Chemical Properties

Dimethyl adipate is a colorless liquid. It is a fatty acid methyl ester.

Uses

Dimethyl adipate is used in cosmetics (in emollients and skin conditioning).It is used as a plasticizer for cellulose-type resins and a finish remover.It is also used in agrochemicals and dye as well as a precursor for the preparation of active pharmaceutical ingredients. Further, it serves as a polymer intermediate. In addition to this, it is employed as a solvent for paint stripping and resins.

Uses

Dimethyl adipate is used in cosmetics (in emollients and skin conditioning). It acts as a cosmetic plasticizer. It is also used in agrochemicals and dye as well as a precursor for the preparation of active pharmaceutical ingredients. Further, it serves as a polymer intermediate. In addition to this, it is employed as a solvent for paint stripping and resins.

Definition

ChEBI: Dimethyl adipate is a fatty acid methyl ester.

Production Methods

Dimethyl adipate is manufactured via esterification of adipic acid and methanol in the presence of an acid catalyst.

General Description

Colorless liquid.

Air & Water Reactions

Flammable. Hydrolyzed by strong mineral acids and strong alkalis.

Reactivity Profile

Dimethyl adipate is an ester. Esters react with acids to liberate heat along with alcohols and acids. Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. Heat is also generated by the interaction of esters with caustic solutions. Flammable hydrogen is generated by mixing esters with alkali metals and hydrides.

Health Hazard

May be harmful by inhalation, ingestion, or skin absorption. May cause irritation.

Health Hazard

Exposures to dimethyl adipate cause toxicity and adverse health effects in laboratory animals and humans. Workplace exposures to dimethyl adipate by inhalation, ingestion, or skin absorption cause harmful and irritation effects to users.

Flammability and Explosibility

Non flammable

Safety Profile

Moderately toxic by intraperitoneal route. Experimental teratogenic and reproductive effects. When heated to decomposition it emits acrid smoke and irritating fumes.

Synthesis

Dimethyl adipate was synthesized by immobilized Candida antarctica lipase B-catalyzed esterification of adipic acid and methanol.

According to the general procedure described above, Dimethyl adipate has been synthesized from adipic acid (730mg, 5 mmol) and methanol (10 ml). Yield: 9%.
1H NMR (400.1 MHz, CDCl3): δ = 3.56 (6H, s, H1-H10), 2.23 (4H, m, H4-H7), 1.56 (4H, m, H5-H6).
13C NMR (100.5 MHz, CDCl3): δ = 173.4 (C3-C8), 51.2 (C1-C10), 33.4 (C4-C7), 24.1 (C5-C6)
https://pubmed.ncbi.nlm.nih.gov/20632329/

Carcinogenicity

In a chronic inhalation toxicity study of dimethyl adipate, groups of male and female rats were exposed to 400 mg/m³ of dimethyl adipate over a 90-day period. Focal respiratory metaplasia of the olfactory epithelium was found. These nonneoplastic lesions were minimal to mild in severity .

Precautions

During handling of dimethyl adipate, occupational workers should be careful and use self-contained breathing apparatus, rubber boots, and heavy rubber gloves and avoid prolonged period of exposures. Workers should avoid contact of dimethyl adipate with skin, eyes and nose.

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