2,2'-Dithiosalicylic acid Chemical Properties

Melting point:

287-290 °C(lit.)

Boiling point:

416.97°C (rough estimate)

Density 

1.4555 (rough estimate)

vapor pressure 

0Pa at 25℃

refractive index 

1.4950 (estimate)

storage temp. 

Refrigerator

solubility 

DMSO (Slightly), Methanol (Slightly)

form 

Powder

pka

3.02±0.36(Predicted)

color 

Brown

Water Solubility 

insoluble

BRN 

2221810

InChIKey

LBEMXJWGHIEXRA-UHFFFAOYSA-N

LogP

1.61 at 25℃ and pH6.2-6.48

CAS DataBase Reference

119-80-2(CAS DataBase Reference)

EPA Substance Registry System

Benzoic acid, 2,2'-dithiobis- (119-80-2)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36-24/25

WGK Germany 

3

RTECS 

DG9660000

Hazard Note 

Harmful/irritant

TSCA 

Yes

HS Code 

29309070

Toxicity

LD50 ipr-mus: 367 mg/kg ARZNAD 21,284,71

MSDS

• Language:English Provider:2,2'-Dithiodibenzoic acid
• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

2,2'-Dithiosalicylic acid Usage And Synthesis

Chemical Properties

brown powder

Uses

2,2'-Dithiosalicylic acid is an organosulfur compound produced from dibenzothiophene metabolites that is in turn biodegraded into transient metabolites such as benzoic acid.It is used in the preparation of a new class of anti-HIV-1 agents.

Uses

2,2′-Dithiodibenzoic acid may be used for the preparation of novel anionic heptadecanuclear silver(I) cluster, by the reaction with equivalent molar silver oxide under ultrasonic conditions at 50°C. It may be used for the preparation of polyamides containing a disulfide bond in their main chain.

General Description

2,2′-Dithiodibenzoic acid is an sulfhydryl modifying reagent. 2,2′-Dithiodibenzoic acid on cocrystallization with imidazole or 4-methylimidazole affords bis(imidazolium) 2,2′-dithiodibenzoate and 4-methylimidazolium 2-[(2-carboxyphenyl)disulfanyl]benzoate organic salt, respectively. It also cocrystallizes with isonicotinohydrazide from methanol solution to afford the 1:2 cocrystal, 2,2′-dithiodibenzoic acid-isonicotinohydrazide.

Safety Profile

Poison by intraperitoneal route.When heated to decomposition it emits toxic vapors ofSOx.

Synthesis

A preparation method of 2,2'-dithiosalicylic acid is as follows: using anthranilic acid as raw material and performing a diazotization reaction with sodium nitrite and hydrochloric acid at 0 to 10°C to obtain a diazo liquid. The liquid reacts with liquid sulfur dioxide for 0.5 to 3 hours in the presence of a catalyst and a cocatalyst at -20~~-10°C and then is kept at 80~100°C for 0.5~2 hours, cooled, and filtered to obtain 2,2'-Dithiosalicylic acid.

2,2'-Dithiosalicylic acid(119-80-2)Related Product Information

• Dilauryl thiodipropionate
• Diphenylthiocarbazide
• TEREPHTHALIC DIHYDRAZIDE
• Terephthalic acid
• Folic acid
• Thiobenzoic acid
• Ethyl 2-(Chlorosulfonyl)acetate
• Citric acid
• Ascoric Acid
• Zinc Dialkyl Dithio Phosphate(ZDDP)
• DIPHENYL DISULFIDE
• Thiosalicylic acid
• Salicylic acid
• 2,2'-Dithiobis(3-methylbenzoic acid)
• dimethyl 2,2'-dithiobisbenzoate
• 2,2'-DITHIOBIS(6-FLUOROBENZOIC ACID)
• 2,2'-Dithiosalicylic acid
• 2,2'-DITHIOSALICYLIC ACID, DISODIUM SALT,2,2'-DITHIOSALICYLIC ACID, DISODIUM SALT