Basic information Safety Supplier Related
ChemicalBook >  Product Catalog >  Chemical Reagents >  Organic reagents >  Thiol / thiol >  2,2'-Dithiosalicylic acid

2,2'-Dithiosalicylic acid

Basic information Safety Supplier Related

2,2'-Dithiosalicylic acid Basic information

Product Name:
2,2'-Dithiosalicylic acid
Synonyms:
  • 2,2'-Dithiodibenzoic acid >=95.0% (NT)
  • 2,2’-dithiobis(benzoicacid)
  • 2,2’-dithiobis-benzoicaci
  • Thimerosal Related Compound A
  • DSTA
  • 2,2'-DITHIOSALICYLIC ACID, TECH., 85%
  • 2-Hydroxybenzenecarbothioic acid
  • 2-Carboxyphenyl disulfide, Bis(2-carboxyphenyl) disulfide, Dithiosalicylic acid
CAS:
119-80-2
MF:
C14H10O4S2
MW:
306.36
EINECS:
204-352-8
Product Categories:
  • pharmacetical
  • Organic acids
  • Aromatics
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Sulfur & Selenium Compounds
  • Halogenated Heterocycles ,Pyrimidines
  • 119-80-2
Mol File:
119-80-2.mol
More
Less

2,2'-Dithiosalicylic acid Chemical Properties

Melting point:
287-290 °C(lit.)
Boiling point:
416.97°C (rough estimate)
Density 
1.4555 (rough estimate)
vapor pressure 
0Pa at 25℃
refractive index 
1.4950 (estimate)
storage temp. 
Refrigerator
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Powder
pka
3.02±0.36(Predicted)
color 
Brown
Water Solubility 
insoluble
BRN 
2221810
InChIKey
LBEMXJWGHIEXRA-UHFFFAOYSA-N
LogP
1.61 at 25℃ and pH6.2-6.48
CAS DataBase Reference
119-80-2(CAS DataBase Reference)
EPA Substance Registry System
Benzoic acid, 2,2'-dithiobis- (119-80-2)
More
Less

Safety Information

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36-24/25
WGK Germany 
3
RTECS 
DG9660000
Hazard Note 
Harmful/irritant
TSCA 
Yes
HS Code 
29309070
Toxicity
LD50 ipr-mus: 367 mg/kg ARZNAD 21,284,71

MSDS

More
Less

2,2'-Dithiosalicylic acid Usage And Synthesis

Chemical Properties

brown powder

Uses

2,2'-Dithiosalicylic acid is an organosulfur compound produced from dibenzothiophene metabolites that is in turn biodegraded into transient metabolites such as benzoic acid.It is used in the preparation of a new class of anti-HIV-1 agents.

Uses

2,2′-Dithiodibenzoic acid may be used for the preparation of novel anionic heptadecanuclear silver(I) cluster, by the reaction with equivalent molar silver oxide under ultrasonic conditions at 50°C. It may be used for the preparation of polyamides containing a disulfide bond in their main chain.

General Description

2,2′-Dithiodibenzoic acid is an sulfhydryl modifying reagent. 2,2′-Dithiodibenzoic acid on cocrystallization with imidazole or 4-methylimidazole affords bis(imidazolium) 2,2′-dithiodibenzoate and 4-methylimidazolium 2-[(2-carboxyphenyl)disulfanyl]benzoate organic salt, respectively. It also cocrystallizes with isonicotinohydrazide from methanol solution to afford the 1:2 cocrystal, 2,2′-dithiodibenzoic acid-isonicotinohydrazide.

Safety Profile

Poison by intraperitoneal route.When heated to decomposition it emits toxic vapors ofSOx.

Synthesis

A preparation method of 2,2'-dithiosalicylic acid is as follows: using anthranilic acid as raw material and performing a diazotization reaction with sodium nitrite and hydrochloric acid at 0 to 10°C to obtain a diazo liquid. The liquid reacts with liquid sulfur dioxide for 0.5 to 3 hours in the presence of a catalyst and a cocatalyst at -20~~-10°C and then is kept at 80~100°C for 0.5~2 hours, cooled, and filtered to obtain 2,2'-Dithiosalicylic acid.

2,2'-Dithiosalicylic acid Preparation Products And Raw materials

Raw materials

2,2'-Dithiosalicylic acidSupplier

Dongying Sifang Litong New Material Co. LTD Gold
Tel
13589435123 17861826421
Email
dysflt@126.com
Beijing Holiyang Chemical Co. Ltd. Gold
Tel
13718199399
Email
holiyangchem@163.com
Wisdom Drugs Co., Ltd. Gold
Tel
18261161868
Email
527536256@qq.com
Hubei Keyijia Chemical Co., Ltd. Gold
Tel
15629167229
Email
1796273473@qq.com
Wuhan Qixinhui Technology Co., Ltd Gold
Tel
027-87002654 18062710658
Email
554831559@qq.com