(R)-PK11195
(R)-PK11195 Basic information
- Product Name:
- (R)-PK11195
- Synonyms:
-
- RP 52028
- (R)-PK11195
- PK 11195
- 1-(2-CHLOROPHENYL)-N-METHYL-N-(1-METHYLPROPYL)-ISOQUINOLINE-3-CARBOXAMIDE-(R)
- 3-ISOQUINOLINECARBOXAMIDE, 1-(2-CHLOROPHENYL)-N-METHYL-N-(1-METHYLPROPYL)-, (R)
- CAS:
- 85340-56-3
- MF:
- C21H21ClN2O
- MW:
- 352.86
- Mol File:
- 85340-56-3.mol
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(R)-PK11195 Chemical Properties
- CAS DataBase Reference
- 85340-56-3
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(R)-PK11195 Usage And Synthesis
Chemical Properties
Yellowish oil
Uses
PK 11195 is a high affinity peripheral benzodiazepine receptor (PBR) ligand. PK 11195 has been shown to regulate protein phosphorylation in rat brain mitochondria under control of Ca2+. PK11195 promotes mitochondrial apoptosis and blocks P-glycoprotein (Pgp)-mediated drug efflux to chemosensitize cancer cells.
Definition
ChEBI: PK-11195 is a monocarboxylic acid amide obtained by formal condensation of the carboxy group of 1-(2-chlorophenyl)isoquinoline-3-carboxylic acid with the amino group of sec-butylmethylamine It has a role as an antineoplastic agent. It is a member of isoquinolines, a monocarboxylic acid amide, an aromatic amide and a member of monochlorobenzenes.