5-Methylpyridine-3-carboxaldehyde Chemical Properties

Melting point:

37 °C

Boiling point:

68 °C(Press: 0.5 Torr)

Density 

1.095±0.06 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

form 

solid

pka

3.72±0.20(Predicted)

Appearance

White to yellow Solid

Safety Information

Hazard Codes 

Xn

Risk Statements 

22

HS Code 

2933399990

5-Methylpyridine-3-carboxaldehyde Usage And Synthesis

Synthesis

Step 2. Synthesis of 5-methyl-3-pyridinecarboxaldehyde. A mixture of 5-methyl-3-pyridinemethanol (106 mg, 0.86 mmol) with activated MnO2 (376 mg) in dichloromethane (10 mL) was reacted at room temperature with stirring overnight. Upon completion of the reaction, the MnO2 black solid was removed by filtration. The filtrate was concentrated under reduced pressure to afford 5-methylpyridine-3-carbaldehyde as a colorless oil (100 mg, 85% yield). The product was characterized by 1H NMR (CDCl3): δ 10.10 (s, 1H), 8.89 (s, 1H), 8.68 (s, 1H), 7.98 (s, 1H), 2.45 (s, 3H).

References

[1] Patent: EP1230232, 2004, B1. Location in patent: Page 40
[2] Journal of Medicinal Chemistry, 2004, vol. 47, # 25, p. 6299 - 6310
[3] Journal of Organic Chemistry, 1988, vol. 53, # 15, p. 3513 - 3521
[4] Patent: WO2016/185423, 2016, A1. Location in patent: Page/Page column 74

5-Methylpyridine-3-carboxaldehyde(100910-66-5)Related Product Information

• Chromium picolinate
• pyridylaldehyde
• 2-Chloro-5-chloromethylpyridine
• 2,6-Lutidine
• 2,4,6-Collidine
• Azamethiphos
• 4-Methylpyridine
• 5-Methylpyridine-3-boronic acid
• 5-METHYL-1H-PYRROLE-2-CARBALDEHYDE
• 5-METHYL-1H-PYRAZOLE-3-CARBOXYLIC ACID METHYL ESTER
• 2-Pyridinecarboxylicacid,5-methyl-,methylester(9CI)
• B-(5-Methyl-1H-Pyrazol-3-Yl)Boronic Acid
• ethyl 5-methylpyridine-2-carboxylate
• (5-methylpyridin-2-yl)methanol
• Diethyl pyridine-3,5-dicarboxylate
• DIETHYL 2,6-DIMETHYL-3,5-PYRIDINEDICARBOXYLATE
• 5-ETHYLPYRIDINE-2,3-DICARBOXYLIC ACID
• 3-METHYLPYRIDINE-4-CARBOXALDEHYDE