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CHOLINE THIEOPHYLLINATE

Basic information Safety Supplier Related

CHOLINE THIEOPHYLLINATE Basic information

Product Name:
CHOLINE THIEOPHYLLINATE
Synonyms:
  • theophyllinecholinate
  • theophyllinesaltofcholine
  • choledyl
  • choledylsa400
  • cholegyl
  • choline,compd.withtheophylline(1:1)
  • cholinetheophyllinesalt
  • cholinophylline
CAS:
4499-40-5
MF:
C12H21N5O3
MW:
283.33
EINECS:
224-798-7
Product Categories:
  • API
Mol File:
4499-40-5.mol
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CHOLINE THIEOPHYLLINATE Chemical Properties

Melting point:
176-178 °C
CAS DataBase Reference
4499-40-5
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Safety Information

HS Code 
2939590000
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CHOLINE THIEOPHYLLINATE Usage And Synthesis

Originator

Sabidal ,S.R. Zyma, UK ,1983

Uses

Bronchodilator.

Uses

Oxytrimethylline is used in the treatment for chronic asthma.

Manufacturing Process

18 parts by weight of theophylline are added to 37.8 parts by weight of aqueous choline bicarbonate (47% assay) and the mixture stirred and heated at 80°C to 90°C until the evolution of carbon dioxide has ceased and complete solution effected. Water is separated from the reaction mixture by distillation under a vacuum sufficient to keep the still temperature between 50°C and 55 C. After about 95 parts by weight of water have been separated, about 80 parts by weight of isopropyl alcohol are added and the mixture subjected to further distillation under a vacuum sufficient to keep the mixture boiling at about 40°C. The distillation removes some of the water as an azeotrope with the isopropyl alcohol. During the removal of the water-isopropyl alcohol azeotrope a crystalline precipitate forms. The mixture is further cooled slowly to 5°C and the crystalline precipitate filtered off. The choline theophyllinate crystals are then washed with isopropyl alcohol and dried under vacuum at about 70°C. A second crop of the product may be obtained from the mother liquor by further reduction in volume and cooling. A yield of 90.5% of theory of choline theophyllinate is obtained completely free of inorganic salts.

brand name

Choledyl(Parke-Davis).

Therapeutic Function

Smooth muscle relaxant

CHOLINE THIEOPHYLLINATE Preparation Products And Raw materials

Raw materials

CHOLINE THIEOPHYLLINATESupplier

Youhua Pharmaceutical (Leshan) Co., Ltd. Gold
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0833-2595508
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2824272261@qq.com
XiaoGan ShenYuan ChemPharm co,ltd
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0712-2580635- ;0712-2580635
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1791901229@qq.com;1791901229@qq.com;
Sinopharm Chemical Reagent Co,Ltd.
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86-21-63210123
Email
sj_scrc@sinopharm.com
Spectrum Chemical Manufacturing Corp.
Tel
021-67601398-809
Email
marketing_china@spectrumchemical.com;
Wuhan Fortuna Chemical Co., Ltd
Tel
027-59207852-
Email
buy@fortunachem.com